{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:43:35Z","timestamp":1791434615545,"version":"4.3.3"},"reference-count":215,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL161205"],"award-info":[{"award-number":["RO1HL161205"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL164794"],"award-info":[{"award-number":["RO1HL164794"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Micro\u2010 and nanoplastics (MNPs) and the tire\u2010derived transformation product 6\u2010PPD\u2010Quinone (6\u2010PPD\u2010Q) have emerged as pervasive environmental pollutants with critical implications for cardiopulmonary health and ecosystem integrity. This review identifies tire wear particles (TWPs) as a primary source of both airborne and waterborne MNPs, as well as 6\u2010PPD, which readily oxidizes into the highly toxic 6\u2010PPD\u2010Q. These contaminants have been detected across diverse environmental compartments including air, soil, water, and remote ecosystems highlighting their global distribution and persistence. Human exposure occurs primarily through inhalation, ingestion, and dermal contact. Although mechanistic studies remain limited, available evidence indicates that MNPs and 6\u2010PPD\u2010Q induce oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and endothelial damage, particularly in pulmonary and cardiovascular tissues. Their detection in human tissues and excreta raises urgent public health concerns. Beyond human health, these toxicants adversely affect soil microbial communities, aquatic organisms, and crop productivity, underscoring their broader ecological footprint within a One Health framework. Regulatory oversight remains limited, especially for nanoplastics and tire\u2010derived compounds, emphasizing the need for standardized detection methods and globally coordinated research and policy initiatives. This review underscores the urgency of implementing comprehensive mitigation strategies, including environmental monitoring, occupational safeguards, and public education, to address the growing threat posed by TWPs, MNPs, and 6\u2010PPD\u2010Q.<\/jats:p>","DOI":"10.1002\/cph4.70092","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T12:37:27Z","timestamp":1767703047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Micro\u2010Nano Plastics and 6\u2010\n                    <scp>PPD<\/scp>\n                    \u2010Q in Cardio\u2010Pulmonary Health: Environmental Sources, Systemic Exposure, and Mechanistic Insights"],"prefix":"10.1002","volume":"16","author":[{"given":"Kunal","family":"Sikder","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Thoracic Medicine and Surgery, Center for Inflammation and Lung Research, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"},{"name":"Department of Biomedical Science &amp; Technology School of Biological Sciences  Kolkata West Bengal India"},{"name":"Department of Sports Science and Yoga School of Rehabilitation and Sports Science, Ramakrishna Mission Vivekananda Educational and Research Institute (RKMVERI)  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Thoracic Medicine and Surgery, Center for Inflammation and Lung Research, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Varma","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Applied Chemistry Kaohsiung Medical University (KMU)  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Saiful","family":"Islam","sequence":"additional","affiliation":[{"name":"Civil and Environmental Engineering Department, College of Engineering Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedjheda","family":"Pierre","sequence":"additional","affiliation":[{"name":"Aging + Cardiovascular Discovery Centre, Department of Cardiovascular Sciences, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeganathan","family":"Chinnadurai","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Applied Chemistry Kaohsiung Medical University (KMU)  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaya Kumar","family":"Gangipangi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Thoracic Medicine and Surgery, Center for Inflammation and Lung Research, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Chien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Applied Chemistry Kaohsiung Medical University (KMU)  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpreet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Physiology and Cell Biology, College of Medicine The Ohio State University Wexner Medical Centre  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-2085","authenticated-orcid":false,"given":"Vinoth Kumar","family":"Ponnusamy","sequence":"additional","affiliation":[{"name":"Department of Medicinal and Applied Chemistry Kaohsiung Medical University (KMU)  Kaohsiung City Taiwan"},{"name":"Research Centre for Precision Environmental Medicine  Kaohsiung City Taiwan"},{"name":"Department of Medical Research Kaohsiung Medical University Hospital Kaohsiung City  Kaohsiung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangadhar","family":"Andaluri","sequence":"additional","affiliation":[{"name":"Civil and Environmental Engineering Department, College of Engineering Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venata Naga Srikanth","family":"Garikipati","sequence":"additional","affiliation":[{"name":"Aging + Cardiovascular Discovery Centre, Department of Cardiovascular Sciences, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-2306","authenticated-orcid":false,"given":"Pawan","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Thoracic Medicine and Surgery, Center for Inflammation and Lung Research, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"},{"name":"Aging + Cardiovascular Discovery Centre, Department of Cardiovascular Sciences, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2022.119526"},{"key":"e_1_2_12_3_1","volume-title":"Microplastics From Tyre and Road Wear a Literature Review","author":"Andersson\u2010Sk\u00f6ld Y.","year":"2020"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171435"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4564"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137823"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2022.129439"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2018.05.047"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2020.117886"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.139874"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1157"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsoil.2023.105202"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12050320"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12050358"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.2c00050"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rsma.2025.104291"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/feart.2024.1349865"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17041212"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c07376"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116756"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-023-00525-x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105343"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b01517"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.14020"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157144"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-015-0172-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.2c00821"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20176667"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.02.010"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.5620\/eaht.e2020004"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-019-7842-0"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.9808002"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020193"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b06362"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5875"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-008-0371-1"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2025.118215"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121254"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b03105"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41370-025-00766-2"},{"key":"e_1_2_12_42_1","volume-title":"Selection of Substances for the 5th Watch List Under the Water Framework Directive","author":"Gomez Cortes L.","year":"2025"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.135266"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116426"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b05297"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.171220"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.164842"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsestwater.3c00589"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.1c00453"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2022.119082"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b00635"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.01.190"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.2346\/tire.18.460408"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101620"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.131495"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.170760"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c03859"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/urbansci9060228"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2024.119492"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23060-8"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000002831"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.162866"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hazadv.2025.100621"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107618"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138950"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.154907"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.156013"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-020-00870-9"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108677"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-7915.14182"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00244-021-00878-4"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117659"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2023.133243"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.impact.2023.100467"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13050579"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.07.050"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.124313"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph14101265"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.51.1.3"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-014-0019-7"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103644"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.136823"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.5334\/aogh.4056"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.142830"},{"issue":"2","key":"e_1_2_12_85_1","article-title":"An Emerging Role of Micro\u2010 and Nanoplastics in Vascular Diseases","volume":"14","author":"Lee S. E.","year":"2024","journal-title":"Life (Basel)"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2023.0048"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108751"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107199"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118190"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107257"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1021\/envhealth.3c00052"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115025"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.2c00366"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.173770"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2013.843025"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2014.945099"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20247162"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2022.339516"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.12.036"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133855"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117477"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.120755"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6AY02415G"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46456"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116689"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2023.106597"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13211788"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.039891"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2309822"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108444"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.06.359"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2021.109056"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.137704"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/jiec.12569"},{"key":"e_1_2_12_115_1","first-page":"1","article-title":"What Is Known and Unknown Concerning Microplastics From Tyre Wear?","volume":"25","author":"Miera\u2010Dominguez H.","year":"2023","journal-title":"Road Materials and Pavement Design"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conbuildmat.2024.139025"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.08.178"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.168236"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.125389"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03453-1"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/gch2.201800118"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10311-023-01593-3"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2023.115645"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atmosenv.2013.01.040"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2021.112897"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2025.178626"},{"issue":"2","key":"e_1_2_12_127_1","article-title":"Microplastics: A Matter of the Heart (And Vascular System)","volume":"11","author":"Persiani E.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1080\/10807039.2025.2566077"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.11.043"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146094"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118102"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.onehlt.2025.101002"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106274"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2023.120835"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c07451"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.01805"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.152619"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2023.117249"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121175"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.1.178"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.3311\/PPch.18930"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2023.118437"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2022.113832"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153628"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0618"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.162644"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2022.118122"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.163576"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-030424-112828"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.177742"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.133169"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-018-0206-z"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emcon.2025.100501"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202211-2099OC"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.125168"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.35.9.644"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/15459624.2017.1302589"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.2478\/kbo-2024-0097"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37551"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14050604"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.167760"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2016.12.004"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2023.119988"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19127511"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn505399e"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.1c00910"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abd6951"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-024-00592-8"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810168"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.08.301"},{"key":"e_1_2_12_171_1","volume-title":"Strategic Vision for Studying Microplastics [Internet]","author":"USGS","year":"2023"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2015.01.008"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127623"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123835"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42452-019-1352-0"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe5041"},{"key":"e_1_2_12_177_1","volume-title":"Microplastics in Road Dust\u2014Characteristics, Pathways and Measures","author":"Vogelsang C.","year":"2018"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2018.03.051"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2024.175057"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137635"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c02584"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.7b00454"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.114125"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c02463"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.152813"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsufs.2018.00081"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23095"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c10248"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2024.133583"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b00423"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.121077"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.161373"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.169260"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.124477"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123228"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c02317"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c03924"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146546"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2025.109316"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123633"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2019.05.037"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.06.004"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107715"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116357"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116554"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.108690"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b04535"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c00087"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics13100873"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.1c04500"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2024.1479292"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.121552"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2023.108171"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.127944"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.3390\/w16081128"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107662"}],"container-title":["Comprehensive Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cph4.70092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cph4.70092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cph4.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:07:40Z","timestamp":1772971660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cph4.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,6]]},"references-count":215,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cph4.70092"],"URL":"https:\/\/doi.org\/10.1002\/cph4.70092","archive":["Portico"],"relation":{},"ISSN":["2040-4603","2040-4603"],"issn-type":[{"value":"2040-4603","type":"print"},{"value":"2040-4603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,6]]},"assertion":[{"value":"2025-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70092"}}