{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:55:39Z","timestamp":1785891339321,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002374\u201007"],"award-info":[{"award-number":["KL2TR002374\u201007"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23CDA1057697"],"award-info":[{"award-number":["23CDA1057697"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL116270"],"award-info":[{"award-number":["T32HL116270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL154624"],"award-info":[{"award-number":["R01HL154624"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL147590"],"award-info":[{"award-number":["R01HL147590"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["TL1 001415"],"award-info":[{"award-number":["TL1 001415"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Pulmonary hypertension (PH) is a heterogeneous disease with patient\u2010specific variability and vessel\u2010specific remodeling, which eventually lead to right ventricular (RV) failure. The gold standard for RV assessment\u2014pressure\u2013volume (PV) loop acquisition\u2014is invasive and limited to specialized settings. This study aims to develop a patient\u2010specific lumped\u2010parameter model that quantifies vessel\u2010specific remodeling and simulates RV PV loops across PH phenotypes using routine clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A lumped\u2010parameter model was calibrated using right heart catheterization and echocardiography data. Model agreement was assessed by\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      values for pressure and flow goodness\u2010of\u2010fit, and model\u2010derived hemodynamic metrics were compared with clinical values. A dimensionality reduction approach was applied to investigate how well different PH phenotypes could be separated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Across the cohort, the lumped\u2010parameter model showed good agreement with clinical data. Model\u2010derived vessel\u2010specific (pulmonary arterial, capillary, venular) parameters highlighted physiological distinctions among phenotypes. Predicted RV PV loops revealed phenotype\u2010specific differences in right ventricular volumes, pressures, and stroke work. The linear discriminant analysis (LDA) demonstrated qualitative separability, indicating that model\u2010derived, nonmeasurable features offer additional discriminatory information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results demonstrate that lumped\u2010parameter models can be calibrated to clinical data to quantify vessel\u2010specific remodeling and simulate RV pressure\u2013volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in\u2010depth pulmonary vascular and RV function in PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cph4.70102","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T06:09:51Z","timestamp":1769494191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient\u2010Specific Lumped\u2010Parameter Model for Quantifying Vessel\u2010Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension"],"prefix":"10.1002","volume":"16","author":[{"given":"Christopher G.","family":"Lechuga","sequence":"first","affiliation":[{"name":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC) and Department of Biomedical Engineering University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2627-942X","authenticated-orcid":false,"given":"Amirreza","family":"Kachabi","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC) and Department of Biomedical Engineering University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2294-9124","authenticated-orcid":false,"given":"Mitchel J.","family":"Colebank","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC) and Department of Biomedical Engineering University of California, Irvine  Irvine California USA"},{"name":"Department of Mathematics University of South Carolina  Columbia South Carolina USA"},{"name":"Department of Biomedical Engineering University of South Carolina  Columbia South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Korcarz","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Cardiovascular Division University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5750-2034","authenticated-orcid":false,"given":"Farhan","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Cardiovascular Division University of Wisconsin\u2013Madison  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7612-5796","authenticated-orcid":false,"given":"Naomi C.","family":"Chesler","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC) and Department of Biomedical Engineering University of California, Irvine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00258.2017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.009101"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105773"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199164"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.024969"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0904"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00766.2023"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2022.0735"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12433"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjimp\/qyae039"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10558-007-9047-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11831-021-09685-5"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13586"},{"key":"e_1_2_11_15_1","volume-title":"Guyton and Hall Textbook of Medical Physiology\/John E. 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