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Myocardial infarction is accompanied by sympathetic stimulation and activation of white adipose tissue and peripheral lipolysis. We therefore investigate here the role of adipocyte ATGL in a murine model of cardiac ischemia and reperfusion (I\/R) by using an inducible, adipocyte specific KO of ATGL (iatATGL\u2010KO). Notably this led to successfully inhibited lipolysis during cardiac ischemia, and KO mice exhibited aggravated cardiac dysfunction and enhanced scar formation after 28\u2009days I\/R. This phenotype went along with multiple structural and molecular alterations mainly in the subcutaneous white adipose tissue depot (iWAT) and brown adipose tissue (BAT). The iatATGL\u2010KO mainly reduced BAT activation as well as adiponectin\u2010secretion. In the heart spatial transcriptomic analysis suggested higher mechanical stress in the remote myocardium, which went along with higher oxygen consumption rates (OCR) and higher dependency on glucose as substrate after 24\u2009h I\/R. Taken together, iatATGL\u2010KO hearts after I\/R seem to be affected in multiple ways, such as a reduction in cardioprotective factors from iWAT and BAT as well as an oxygen wasting effect in the remote zone of the heart, which contribute to the worse outcome. This indicates a time and depot\u2010specific role of adipocyte ATGL in cardiac ischemia and reperfusion injury.<\/jats:p>","DOI":"10.1002\/cph4.70106","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T20:15:07Z","timestamp":1770236107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ATGL<\/scp>\n                    From\n                    <scp>iWAT<\/scp>\n                    and\n                    <scp>BAT<\/scp>\n                    Is Crucial for Cardiac Remodeling and Metabolism After Myocardial Ischemia\/Reperfusion"],"prefix":"10.1002","volume":"16","author":[{"given":"Heba","family":"Zabri","sequence":"first","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa","family":"Ucar","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Gorressen","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Kretschmer","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Gorski","sequence":"additional","affiliation":[{"name":"Institute for Pharmacology, Medical Faculty and University Hospital D\u00fcsseldorf Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Lautwein","sequence":"additional","affiliation":[{"name":"Genomics &amp; Transcriptomics Laboratory (GTL) of the Heinrich\u2010Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Balan","sequence":"additional","affiliation":[{"name":"Core Unit Bioinformatics (CUBI) Medical Faculty and University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Lehr","sequence":"additional","affiliation":[{"name":"Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center (DDZ) Leibniz Center for Diabetes Research at Heinrich Heine University D\u00fcsseldorf  D\u00fcsseldorf Germany"},{"name":"German Center for Diabetes Research (DZD e.V.)  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