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Acting through oxidation\u2010dependent modulation of Cys106, DJ\u20101 integrates cellular redox cues with mitochondrial function, insulin signaling, and stress adaptation pathways. In pancreatic \u03b2\u2010cells, it preserves stimulus secretion coupling by stabilizing mitochondrial ATP production. In liver and adipose tissue, DJ\u20101 maintains insulin responsive signaling and metabolic flexibility through PTEN\u2013PI3K\u2013Akt and antioxidant networks. Loss or over\u2010oxidation of DJ\u20101 disrupts interorgan glucose coordination, linking chronic redox imbalance to dysglycemia. This review positions DJ\u20101 as a metabolic sentinel translating oxidative inputs into integrated glucose regulatory outputs.<\/jats:p>","DOI":"10.1002\/cph4.70123","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:29:41Z","timestamp":1773638981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DJ<\/scp>\n                    \u20101 (\n                    <scp>PARK7<\/scp>\n                    ) as a Redox\u2010Responsive Integrator of Pancreatic, Hepatic, and Adipose Crosstalk in Glucose Homeostasis"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1979-9787","authenticated-orcid":false,"given":"Jayasingha Mudiyanselage Pavithra Sewwandi","family":"Jayasingha","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences University of Sri Jayewardenepura  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