{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:57:38Z","timestamp":1793383058450,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010215","name":"Deutsche Diabetes Gesellschaft","doi-asserted-by":"publisher","award":["Projektf\u00f6rderung to SB"],"award-info":[{"award-number":["Projektf\u00f6rderung to SB"]}],"id":[{"id":"10.13039\/501100010215","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 412\/1\u2013535081457"],"award-info":[{"award-number":["TRR 412\/1\u2013535081457"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201808650045"],"award-info":[{"award-number":["201808650045"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Comprehensive Physiology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The potassium channel KCNK16 (TALK\u20101) is highly expressed in murine and human pancreas and has been implicated in regulating \u03b2\u2010cell electrical excitability and glucose\u2010stimulated insulin secretion (GSIS). Genetic studies have linked KCNK16 variants to type 2 diabetes (T2D), yet its physiological role in\u00a0vivo remains largely unexplored. We aimed to characterize the cardiometabolic functions of KCNK16 in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Male constitutive\n                      <jats:italic>Kcnk16<\/jats:italic>\n                      \u2010deficient mice (KCNK16\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      ) were characterized on standard (STD) or high\u2010fat diet (HFD) for up to 21\u2009weeks. Phenotyping included measurements of body weight and composition, echocardiography, blood pressure, and indirect calorimetry. Insulin and glucose homeostasis were assessed by tolerance tests and glucose clamp studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      KCNK16\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice showed lower weight gain, less fat and lean mass, reduced diet intake, and shorter body length across diets. Glucose tolerance, insulin sensitivity, hepatic lipid content, and cardiac function remained largely unaffected, except for lower systolic blood pressure under STD. During HFD, KCNK16\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      mice exhibited increased energy expenditure but attenuated first\u2010phase insulin secretion. Pancreatic insulin content was elevated while circulating IGF\u20101 was diminished.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Kcnk16<\/jats:italic>\n                      deficiency reduced somatic growth and body weight and altered energy expenditure, accompanied by modest changes in insulin secretion dynamics, while glucose homeostasis remained preserved.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cph4.70180","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:23:02Z","timestamp":1780035782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>KCNK<\/scp>\n                    16 Deficiency Deteriorates Body Growth and Diet\u2010Independently Decreases Lipid Accumulation in Mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Olena","family":"Fr\u00fch","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Diseases (ENDO\u2010ERN) Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Berlin Institute of Health at Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charit\u00e9 Junior Clinician Scientist Program  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Diseases (ENDO\u2010ERN) Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana M.","family":"J\u00e4ger","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Diseases (ENDO\u2010ERN) Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongwan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Diseases (ENDO\u2010ERN) Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoxue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, European Reference Network on Rare Endocrine Diseases (ENDO\u2010ERN) Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-0798","authenticated-orcid":false,"given":"Niklas","family":"Hegemann","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC), Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Institute of Physiology Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Grune","sequence":"additional","affiliation":[{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin  Berlin Germany"},{"name":"Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charit\u00e9 (DHZC), Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Institute of Physiology Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"German Centre for Lung Research  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuyo","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Infectious Diseases and Immunology Charit\u00e9 \u2014 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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