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This chronic and complex disease is related to the development of many life\u2010threatening illnesses including cardiovascular diseases. Hypertension caused by obesity increases the risk for cardiovascular mortality and morbidity by promoting stroke, myocardial infarction, congestive heart failure, and end\u2010stage renal disease. Overwhelming evidence supports neural origins for obesity\u2010induced hypertension and pinpoints the adipose\u2010derived hormone, leptin, and the sympathetic nervous system as major causal factors. Hyperleptinemia in obesity is associated with selective leptin resistance where leptin's renal sympathoexcitatory and pressor effects are preserved while the metabolic actions are impaired. Understanding the mechanisms driving this phenomenon is critical for developing effective therapeutics. This review describes the neural mechanisms of obesity\u2010induced hypertension with a focus on the molecular and neuronal substrates of leptin action.<\/jats:p>","DOI":"10.1002\/cph4.8","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T07:03:37Z","timestamp":1734937417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Leptin and Associated Neural Pathways Underlying Obesity\u2010Induced Hypertension"],"prefix":"10.1002","volume":"15","author":[{"given":"Connor","family":"Laule","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Pharmacology University of Iowa Carver College of Medicine  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-6748","authenticated-orcid":false,"given":"Kamal","family":"Rahmouni","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and 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