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Here we demonstrate the use of deoxyribozyme\u2010based logic gate networks arranged into visual displays to precisely control activation of biosensors, and demonstrate a prototype molecular automaton able to discriminate between seven different genotypes of <jats:italic>Lyssavirus<\/jats:italic>es, including Rabies virus. The device uses novel mixed\u2010base logic gates to enable detection of the large diversity of <jats:italic>Lyssavirus<\/jats:italic> sequence populations, while an ANDNOT logic gate prevents non\u2010specific activation across genotypes. The resultant device provides a user\u2010friendly digital\u2010like, but molecule\u2010powered, dot\u2010matrix text output for unequivocal results read\u2010out that is highly relevant for point of care applications.<\/jats:p>","DOI":"10.1002\/cphc.201700072","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T06:02:44Z","timestamp":1490421764000},"page":"1735-1741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A DNA Logic Gate Automaton for Detection of Rabies and Other <i>Lyssaviruses<\/i>"],"prefix":"10.1002","volume":"18","author":[{"given":"Pavithra","family":"Vijayakumar","sequence":"first","affiliation":[{"name":"Division of Experimental Therapeutics, Department of Medicine Columbia University  630 W 168<sup>th<\/sup>St New York NY 10032 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4624-3545","authenticated-orcid":false,"given":"Joanne","family":"Macdonald","sequence":"additional","affiliation":[{"name":"Division of Experimental Therapeutics, Department of Medicine Columbia University  630 W 168<sup>th<\/sup>St New York NY 10032 USA"},{"name":"Genecology Research Centre; Inflammation and Healing Research Cluster, School of Science and Engineering University of the Sunshine Coast  Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"e_1_2_2_1_1","unstructured":"\u00a0"},{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja016756v"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja0296632"},{"key":"e_1_2_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt862"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0620684"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402698"},{"key":"e_1_2_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201402698"},{"key":"e_1_2_2_7_1","unstructured":"\u00a0"},{"key":"e_1_2_2_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi051871u"},{"key":"e_1_2_2_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/ja043003a"},{"key":"e_1_2_2_10_1","first-page":"360","volume":"83","author":"Knobel D. 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