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In this work we demonstrate how it can be done by introducing deuterium into the crystal lattice of organic compounds which tend to form hydrates. In our studies we explored H\u2013D exchange in the crystals stored in contact with deuterium oxide vapors. Employing barbituric acid (BA) and (+)\u2010catechin (CAT) as model samples and by using advanced solid\u2010state NMR spectroscopy and mass spectrometry, we revealed that not only OH and NH protons of these chemicals undergo exchange to deuterium in a crystal lattice, but also usually immobile protons, that is, (Ar)CH (in CAT) and CH<jats:sub>2<\/jats:sub> (in BA) are exchanged as a result of keto\u2013enol tautomerism.<\/jats:p>","DOI":"10.1002\/cphc.201700678","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T10:16:49Z","timestamp":1500373009000},"page":"2850-2854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Spontaneous Keto\u2013Enol Tautomerization in the Crystal Lattice Visualized with the Help of Water Encapsulated in Hydrophilic 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