{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:10:51Z","timestamp":1787505051525,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPhysChem"],"published-print":{"date-parts":[[2021,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The potential role of cyanide\u2010bridged platinum\u2010iron complexes as an anti\u2010cancer Pt(IV) prodrug is studied. We present design principles of a dual\u2010function prodrug that can upon reduction dissociate and release concurrently six cisplatin units and a ferricyanide anion per prodrug unit. The prodrug molecule is a unique complex of hepta metal centers consisting of a ferricyanide core with six Pt(IV) centers each bonded to the Fe(III) core through a cyano ligand. The functionality of the prodrug is addressed through density functional theory (DFT) calculations.<\/jats:p>","DOI":"10.1002\/cphc.202000748","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T14:55:39Z","timestamp":1603551339000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cyanide Bridged Platinum\u2010Iron Complexes as Cisplatin Prodrug Systems: Design and Computational Study"],"prefix":"10.1002","volume":"22","author":[{"given":"Ariela W.","family":"Kaspi\u2010Kaneti","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Kent State University  Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijana","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Kent State University  Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Kent State University  Kent OH 44242 USA"},{"name":"Present address: Institute of Physical Chemistry Friedrich Schiller University Jena  07743 Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songping D.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Kent State University  Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6982-8995","authenticated-orcid":false,"given":"Barry D.","family":"Dunietz","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Kent State University  Kent OH 44242 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/205698a0"},{"key":"e_1_2_8_2_1","unstructured":"National institutes of health. clinical trials database. accessed: 2015.http:\/\/www.clinicaltrials.gov."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm3016427"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.5b00597"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00128"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"9598","DOI":"10.1002\/ange.201003185","volume":"122","author":"Ting V. P.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201707683"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b07875"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/235282a0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980421n"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-5-704"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2012.06.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b13681"},{"key":"e_1_2_8_14_1","first-page":"1402","volume":"49","author":"Gibbons G. R.","year":"1989","journal-title":"Cancer Res."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm070280u"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5956-9-68"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809154105"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja5029765"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b03386"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201903112"},{"key":"e_1_2_8_21_1","first-page":"418","volume":"52","author":"Shi Y.","year":"2013","journal-title":"Inorg. Chem."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201916400"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja507131q"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100180a044"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp0363038"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.4731882"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar700111a"},{"key":"e_1_2_8_28_1","first-page":"85","volume":"37","author":"Lee C.","year":"1988","journal-title":"Phys. Rev. B"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/b810189b"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.30"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3545971"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CP05680A"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3382344"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja971838y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9904009"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.3511297"},{"key":"e_1_2_8_37_1","first-page":"509","author":"Lange A. W.","year":"2011","journal-title":"Chem. Phys. Lett."},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2014.952696"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-017-0175-0"},{"key":"e_1_2_8_40_1","first-page":"56","author":"Shatruk M.","year":"2009","journal-title":"Prog. Inorg. Chem."},{"key":"e_1_2_8_41_1","first-page":"48","author":"Yu F.","year":"2014","journal-title":"Inorg. Chem. Commun."},{"key":"e_1_2_8_42_1","doi-asserted-by":"crossref","unstructured":"C.\u2005J. Mordas B.\u2005W. Pfennig A.\u2005B. Bocarsly E. Schreiber. Ultrafast pump-probe and resonance raman spectroscopic study of excited state electronic coupling in two related hexanuclear charge transfer compounds. InInternational Conference on Ultrafast Phenomena page WD21. Optical Society of America 2002.","DOI":"10.1364\/UP.2002.WD21"},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1021\/ic020232u","volume":"41","author":"Pfennig B. W.","year":"2002","journal-title":"Inorg. Chem."},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2004.07.032"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2012.08.024"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.22270\/ujpr.v2i3.RW5","volume":"2","author":"Chigbo U. J.","year":"2017","journal-title":"Univers. J. Pharm. Res."},{"key":"e_1_2_8_47_1","first-page":"5151","volume":"48","author":"Lian H.-Y.","year":"2012","journal-title":"ChemComm"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13008"},{"key":"e_1_2_8_49_1","unstructured":"Ohio supercomputer center. http:\/\/osc.edu\/ark:\/19495\/f5\u2005s1ph73."}],"container-title":["ChemPhysChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphc.202000748","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cphc.202000748","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphc.202000748","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:41:20Z","timestamp":1760370080000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cphc.202000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,26]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,7]]}},"alternative-id":["10.1002\/cphc.202000748"],"URL":"https:\/\/doi.org\/10.1002\/cphc.202000748","archive":["Portico"],"relation":{},"ISSN":["1439-4235","1439-7641"],"issn-type":[{"value":"1439-4235","type":"print"},{"value":"1439-7641","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,26]]},"assertion":[{"value":"2020-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}