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[Ir(IMes)(COD)Cl] (IMes=1,3\u2010\n                    <jats:italic>bis<\/jats:italic>\n                    (2,4,6\u2010trimethylphenyl)imidazole\u20102\u2010ylidene, COD=cyclooctadiene) was employed as the polarisation transfer catalyst. Following polarisation transfer at 6.5 mT, the pyrazine\u2010protons were enhanced by 78\u2010fold (polarisation, P=0.04\u2009%). The complex [Ir(IMes)(H)\n                    <jats:sub>2<\/jats:sub>\n                    (mirfentanil)\n                    <jats:sub>2<\/jats:sub>\n                    (MeOH)]\n                    <jats:sup>+<\/jats:sup>\n                    is proposed to form based on the observation of two hydrides at \u03b4 \u221222.9 (\n                    <jats:italic>trans<\/jats:italic>\n                    to mirfentanil) and \u221224.7 (\n                    <jats:italic>trans<\/jats:italic>\n                    to methanol). In a mixture of mirfentanil and heroin, the former could be detected using SABRE at concentrations less than 1\u2009% w\/w. At the lowest concentration analyzed, the amount of mirfentanil present was 0.18\u2005mg (812\u2005\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M) and produced a signal enhancement of \u2212867\u2010fold (P=0.42\u2009%). following polarisation transfer at 6.5\u2005mT.\n                  <\/jats:p>","DOI":"10.1002\/cphc.202100165","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:47:05Z","timestamp":1618832825000},"page":"1059-1064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperpolarisation of Mirfentanil by SABRE in the Presence of Heroin"],"prefix":"10.1002","volume":"22","author":[{"given":"Thomas B. R.","family":"Robertson","sequence":"first","affiliation":[{"name":"Department of Natural Sciences Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"},{"name":"Current address: School of Chemistry University of Southampton  SO17 1BJ Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"},{"name":"MANchester DRug Analysis and Knowledge Exchange (MANDRAKE) Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver B.","family":"Sutcliffe","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"},{"name":"MANchester DRug Analysis and Knowledge Exchange (MANDRAKE) Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-6505","authenticated-orcid":false,"given":"Ryan E.","family":"Mewis","sequence":"additional","affiliation":[{"name":"Department of Natural Sciences Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"},{"name":"MANchester DRug Analysis and Knowledge Exchange (MANDRAKE) Manchester Metropolitan University  John Dalton Building, Chester St. Manchester M1 5GD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,11]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3501(95)80053-0"},{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S0022-3565(25)20240-3","volume":"258","author":"France C. 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