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With different dopants in [Al<jats:italic>X<\/jats:italic>O<jats:sub>3<\/jats:sub>]<jats:sup>+<\/jats:sup>, the mechanism, reactivity and selectivity towards methane activation varies accordingly. The classic HAT competes with PCET, depending on the composition of intramolecular interactions. Although the existence of terminal oxygen radical is beneficial for classic HAT, the Al<jats:sub>t<\/jats:sub>\u2212C interaction in the [Al<jats:italic>X<\/jats:italic>O<jats:sub>3<\/jats:sub>]<jats:sup>+<\/jats:sup> clusters as enhanced by the strongly electronegative doping groups (<jats:italic>X<\/jats:italic>=Al, AlZnO, Mg, Zn, VO, NbO, TaO) favors the PCET process, facilitating C\u2212H bond breaking. In addition, with different dopants, the destiny of the split methyl group varies accordingly. While strong interaction between Al<jats:sub>t<\/jats:sub> and CH<jats:sub>3<\/jats:sub> results in the formation of the Al<jats:sub>t<\/jats:sub>\u2212C bond, dopants with variable valance may promote the formation of deep\u2010oxidation products like formaldehyde. It has been discussed in detail how to regulate the activity and selectivity of the active center of the catalyst via rational doping.<\/jats:p>","DOI":"10.1002\/cphc.202200949","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T05:02:12Z","timestamp":1677128532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["How Doping Affects the Activity of the Aluminum Oxide Support"],"prefix":"10.1002","volume":"24","author":[{"given":"Linghui","family":"Yan","sequence":"first","affiliation":[{"name":"College of Chemical and Biological Engineering Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology Zhejiang University  310027 Hangzhou P. R. China"},{"name":"Institute of Zhejiang University \u2013 Quzhou  Zheda Rd. #99 324000 Quzhou P.R. 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