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Here, we report the first formation of the cyclic acetaldehyde trimer \u2013 paraldehyde (C<jats:sub>6<\/jats:sub>H<jats:sub>12<\/jats:sub>O<jats:sub>3<\/jats:sub>) \u2013 in low\u2010temperature interstellar analog ices exposed to energetic irradiation as proxies of galactic cosmic rays (GCRs). Utilizing vacuum ultraviolet photoionization reflectron time\u2010of\u2010flight mass spectrometry and isotopic substitution experiments, paraldehyde was identified in the gas phase during the temperature\u2010programmed desorption of the irradiated acetaldehyde ices based on the calculated adiabatic ionization energies and isomer\u2010specific dissociative fragmentation patterns upon photoionization. As acetaldehyde is ubiquitous throughout the interstellar medium and has been tentatively identified in interstellar ices, paraldehyde could have formed in acetaldehyde\u2010containing ices in a cold molecular cloud and is an excellent candidate for gas\u2010phase observation in star\u2010forming regions via radio telescopes. The identification of paraldehyde in the gas phase from the processed acetaldehyde ices advances our understanding of how complex organic molecules can be synthesized through polymerization reactions in extraterrestrial ices exposed to GCRs.<\/jats:p>","DOI":"10.1002\/cphc.202400837","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T03:10:36Z","timestamp":1728011436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Formation of Paraldehyde (C<sub>6<\/sub>H<sub>12<\/sub>O<sub>3<\/sub>) in Interstellar Analog Ices of Acetaldehyde Exposed to Ionizing Radiation"],"prefix":"10.1002","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-8699","authenticated-orcid":false,"given":"Jia","family":"Wang","sequence":"first","affiliation":[{"name":"W. M. 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