{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:39:31Z","timestamp":1790797171864,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPhysChem"],"published-print":{"date-parts":[[2025,8,23]]},"abstract":"<jats:p>\n                    Information regarding the dimension and the shape of molecules in solution represents a holy grail for chemists. Recently, newly designed surface plasmon resonance (SPR) methods to precisely measure the diffusion coefficients (\n                    <jats:italic>D<\/jats:italic>\n                    ) (D\u2010SPR) have been developed and applied successfully to a variety of molecules, ranging from diverse long\u2010chain alcohols to protein conformers and oligomers involved in conformational disorders, mostly represented by neurodegenerative processes of nervous tissues of the brain and retina. The dependence of\n                    <jats:italic>D<\/jats:italic>\n                    on the molecular size, shape, and oligomerization state of different molecules has been widely investigated, opening up new avenues and tools for chemical, biochemical, and clinical research. Herein, the historical basis and the development of the newly proposed D\u2010SPR method are briefly described to obtain meaningful information about molecular features that are otherwise hard to characterize using more common and traditional bioanalytical approaches.\n                  <\/jats:p>","DOI":"10.1002\/cphc.202500138","type":"journal-article","created":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T21:10:36Z","timestamp":1751231436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Broad\u2010Spectrum Diffusion Coefficient Measurements via Surface Plasmon Resonance: From Thermodynamics to Protein Conformational Disorders"],"prefix":"10.1002","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1258-8702","authenticated-orcid":false,"given":"Giuseppe Stefano","family":"Basile","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences University of Catania  Viale Andrea Doria 6 95125 Catania Italy"},{"name":"Scuola Superiore di Catania University of Catania  Via Valdisavoia 9 95123 Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6105-5983","authenticated-orcid":false,"given":"Damiano","family":"Calcagno","sequence":"additional","affiliation":[{"name":"IRCCS\u2010Fondazione Bietti  Via Livenza 3 00198 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-0406","authenticated-orcid":false,"given":"Nunzio","family":"Tuccitto","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Catania  Viale Andrea Doria 6 95125 Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-7761","authenticated-orcid":false,"given":"Diego","family":"Sbardella","sequence":"additional","affiliation":[{"name":"IRCCS\u2010Fondazione Bietti  Via Livenza 3 00198 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7179-4835","authenticated-orcid":false,"given":"Giuseppe","family":"Grasso","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences University of Catania  Viale Andrea Doria 6 95125 Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Modern Thermodynamics: From Heat Engines to Dissipative Structures","author":"Kondepudi D.","year":"2015"},{"key":"e_1_2_9_3_1","volume-title":"The Mathematics of Diffusion","author":"Crank J.","year":"1980"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/906136"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.4c00021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.047985"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-4-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.36"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR06999J"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202402346"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-54089-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9112\/7\/10\/012"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7PY01577A"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC00670H"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-6203.31148"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspa.1953.0139"},{"key":"e_1_2_9_17_1","volume-title":"Statistical Mechanics","author":"McQuarrie D. 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