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Due to the role played by SAM and its antioxidant properties, the one electron oxidation products of SAM produced by gamma radiolysis, which can mimic the oxidation effect produced by hydroxyl radical in the oxidative stress process, have been investigated in this study by collision\u2010induced dissociation tandem mass spectrometry (CID\u2010MS\n                    <jats:sup>2<\/jats:sup>\n                    ) and infrared multiple photon dissociation spectroscopy (IRMPD). We have revealed the modified sites in the molecule and characterized the 3D structure of the oxo\u2010forms of SAM in the gas phase. Both CID\u2010MS\n                    <jats:sup>2<\/jats:sup>\n                    and IRMPD experiments, when coupled with quantum chemistry calculations have shown that only the adenine moiety of the molecule is oxidized, protecting the methionine from oxidation.\n                  <\/jats:p>","DOI":"10.1002\/cphc.70462","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T01:55:15Z","timestamp":1782179715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxidation Products of S\u2010Adenosyl Methionine Probed by Infrared Multiple Photon Dissociation Spectroscopy"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5731-222X","authenticated-orcid":false,"given":"Jean\u2010Xavier","family":"Bardaud","sequence":"first","affiliation":[{"name":"CNRS Universit\u00e9 Paris\u2010Saclay, CNRS, Institut de Chimie Physique  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Jiang","sequence":"additional","affiliation":[{"name":"CNRS Universit\u00e9 Paris\u2010Saclay, CNRS, Institut de Chimie Physique  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5531-2333","authenticated-orcid":false,"given":"Carine","family":"Clavaguera","sequence":"additional","affiliation":[{"name":"CNRS Universit\u00e9 Paris\u2010Saclay, CNRS, Institut de Chimie Physique  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8089-796X","authenticated-orcid":false,"given":"Chantal","family":"Hou\u00e9e\u2010Levin","sequence":"additional","affiliation":[{"name":"CNRS Universit\u00e9 Paris\u2010Saclay, CNRS, Institut de Chimie Physique  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-922X","authenticated-orcid":false,"given":"Giel","family":"Berden","sequence":"additional","affiliation":[{"name":"HFML\u2010FELIX  Nijmegen The Netherlands"},{"name":"Institute for Molecules and Materials Radboud University  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-1278","authenticated-orcid":false,"given":"Jos","family":"Oomens","sequence":"additional","affiliation":[{"name":"HFML\u2010FELIX  Nijmegen The Netherlands"},{"name":"Institute for Molecules and Materials Radboud University  Nijmegen The Netherlands"},{"name":"van\u2019t Hoff Institute for Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-8481","authenticated-orcid":false,"given":"Debora","family":"Scuderi","sequence":"additional","affiliation":[{"name":"CNRS Universit\u00e9 Paris\u2010Saclay, CNRS, Institut de Chimie Physique  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.062"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01131a519"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(99)00139-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr4004709"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00086E"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.5.1183S"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.013"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011286.pub2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170177"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(97)00124-X"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.05.039"},{"key":"e_1_2_9_13_1","article-title":"Radiation Chemistry","author":"Spotheim\u2010Maurizot M.","year":"2008","journal-title":"EDP Sciences"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00395"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.6b12638"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2013.10.057"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CP03223G"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c06541"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.202300534"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0045-2068(87)90008-3"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200503942"},{"key":"e_1_2_9_22_1","volume-title":"An Introduction to Radiation Chemistry","author":"Spinks J. 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