{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:19:35Z","timestamp":1791137975005,"version":"4.1.0"},"edition-number":"1","reference-count":159,"publisher":"Wiley","isbn-type":[{"value":"9780470650714","type":"electronic"}],"license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary arterial hypertension (PAH) is a fatal disease characterized by impaired regulation of pulmonary hemodynamics and excessive growth and dysfunction of the endothelial cells that line the arteries in PAH lungs. Establishment of methods for culture of pulmonary artery endothelial cells from PAH lungs has provided the groundwork for mechanistic translational studies that confirm and extend findings from model systems and spontaneous pulmonary hypertension in animals. Endothelial cell hyperproliferation, survival, and alterations of biochemical\u2010metabolic pathways are the unifying endothelial pathobiology of the disease. The hyperproliferative and apoptosis\u2010resistant phenotype of PAH endothelial cells is dependent upon the activation of signal transducer and activator of transcription (STAT) 3, a fundamental regulator of cell survival and angiogenesis. Animal models of PAH, patients with PAH, and human PAH endothelial cells produce low nitric oxide (NO). In association with the low level of NO, endothelial cells have reduced mitochondrial numbers and cellular respiration, which is associated with more than a threefold increase in glycolysis for energy production. The shift to glycolysis is related to low levels of NO and likely to the pathologic expression of the prosurvival and proangiogenic signal transducer, hypoxia\u2010inducible factor (HIF)\u20101, and the reduced mitochondrial antioxidant manganese superoxide dismutase (MnSOD). In this article, we review the phenotypic changes of the endothelium in PAH and the biochemical mechanisms accounting for the proliferative, glycolytic, and strongly proangiogenic phenotype of these dysfunctional cells, which consequently foster the panvascular progressive pulmonary remodeling in PAH. \u00a9 2011 American Physiological Society.<jats:italic>Compr Physiol<\/jats:italic>1:357\u2010372, 2011.<\/jats:p>","DOI":"10.1002\/cphy.c090005","type":"other","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T18:06:10Z","timestamp":1290017170000},"page":"357-372","source":"Crossref","is-referenced-by-count":42,"title":["Endothelial Cell Energy Metabolism, Proliferation, and Apoptosis in Pulmonary Hypertension"],"prefix":"10.1002","author":[{"given":"Weiling","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil C.","family":"Erzurum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071545"},{"key":"e_1_2_6_3_1","first-page":"31","article-title":"The physiological and biochemical effects of diabetes on the balance between oxidative stress and antioxidant defense system","volume":"15","author":"Ahmed RG","year":"2005","journal-title":"Med J Islamic World Acad Sci"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000057847.32590.C1"},{"key":"e_1_2_6_5_1","first-page":"A6010","article-title":"Acquired genetic abnormalities in the lungs of patients with pulmonary arterial hypertension","volume":"179","author":"Aldred MA","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000110785.96039.f6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339908783502398"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000073585.50092.14"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(85)90015-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405368101"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.22.2781"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01324.2007"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070705"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000012754.72951.3D"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.16.6421"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-001-0006-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1084fje"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.07.029"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/34657"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.609008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0741356"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-147OC"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2004.03.016"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15496"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1124"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/83.2.259"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182225899"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11715"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001914200"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2005.04.022"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00491.2001"},{"key":"e_1_2_6_32_1","first-page":"379","article-title":"Derangements of the nitric oxide synthase pathway, l\u2010arginine, and cardiovascular diseases","volume":"96","author":"Cooke JP","year":"1997","journal-title":"Circulation"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(97)90032-0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65137-1"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.21.4.496"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.6.2104033"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.1.C205"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8197455"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1086\/303059"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1378"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3862"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MCBI.0000026047.48534.50"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI36136"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10561"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M308504200"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.312.5777.1158"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.7508323"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1478"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507273330403"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3176.bloodjournal8883176"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1684OC"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01338-07"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088805"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.18.4.533"},{"key":"e_1_2_6_55_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.33549\/physiolres.930000.49.493","article-title":"A possible role of the oxidant tissue injury in the development of hypoxic pulmonary hypertension","volume":"49","author":"Herget J","year":"2000","journal-title":"Physiol Res"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.4.1299"},{"key":"e_1_2_6_57_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1055\/s-0038-1646177","article-title":"Nitric oxide\u2010mediated vasorelaxation","volume":"70","author":"Ignarro LJ","year":"1993","journal-title":"Thromb Haemost"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.4.485"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/ps\/80.5.656"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90088-8"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634709"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1053\/pcad.2002.130041"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3099fje"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2635"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.3.9802066"},{"key":"e_1_2_6_66_1","doi-asserted-by":"crossref","first-page":"H981","DOI":"10.1152\/ajpheart.2001.281.3.H981","article-title":"Vascular endothelial dysfunction: Does tetrahydrobiopterin play a role","volume":"281","author":"Katusic ZS","year":"2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2005"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000162470.26840.89"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2003.11.006"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.1.102"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199811000-00006"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-676OC"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/79226"},{"key":"e_1_2_6_74_1","first-page":"235","article-title":"Effects of dimethylthiourea on chronic hypoxia\u2010induced pulmonary arterial remodelling and ventricular hypertrophy in rats","volume":"12","author":"Langleben D","year":"1989","journal-title":"Clin Invest Med"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1910"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.24.15257"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.263.2.C326"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.04.015"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2004.06.039"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<313::AID-PATH93>3.0.CO;2-8"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2008.00035.x"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00428.2006"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031155"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000141576.39579.23"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1126863"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(99)00034-9"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2003.11.014"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.033"},{"key":"e_1_2_6_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0202.101974"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2008.09.004"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20020591"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/014107689909200402"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm762"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00377.2007"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031605"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169660"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000163268.32638.F4"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90266-6"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079368"},{"key":"e_1_2_6_100_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405432101"},{"key":"e_1_2_6_101_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.165.2.500"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004080000064"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03668-2"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(96)00048-2"},{"key":"e_1_2_6_105_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.0146"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.21.2169"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601026103"},{"key":"e_1_2_6_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33452"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(02)01142-5"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0502267102"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105408200"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-009-9215-9"},{"key":"e_1_2_6_113_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3261fje"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00164-9"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00463.2006"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1187"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147949"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104718200"},{"key":"e_1_2_6_119_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00247.2007"},{"key":"e_1_2_6_120_1","doi-asserted-by":"publisher","DOI":"10.1089\/104303403321618128"},{"key":"e_1_2_6_121_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1993.tb18025.x"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.02.037"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-007-0735-3"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.6_suppl.558S"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(99)00016-X"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470123119.ch8"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00005-3"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0343com"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.6.L1005"},{"key":"e_1_2_6_130_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.10.741"},{"key":"e_1_2_6_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03265-9"},{"key":"e_1_2_6_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.953"},{"key":"e_1_2_6_133_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117858"},{"key":"e_1_2_6_134_1","first-page":"275","article-title":"Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension","volume":"144","author":"Tuder RM","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_135_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1_Supplement.1S-a"},{"key":"e_1_2_6_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2006.11.010"},{"key":"e_1_2_6_137_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.276.2.L297"},{"key":"e_1_2_6_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.02.007"},{"key":"e_1_2_6_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00230-8"},{"key":"e_1_2_6_140_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10541-005-0090-7"},{"key":"e_1_2_6_141_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.3_Supplement.225S"},{"key":"e_1_2_6_142_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1482"},{"key":"e_1_2_6_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/261702a0"},{"key":"e_1_2_6_144_1","first-page":"319","article-title":"Ueber den Stoffwechsel der Tumoren","volume":"152","author":"Warburg O","year":"1924","journal-title":"Biochem Zeitschrift"},{"key":"e_1_2_6_145_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000142232.29764.a7"},{"key":"e_1_2_6_146_1","doi-asserted-by":"publisher","DOI":"10.1089\/152308603770380061"},{"key":"e_1_2_6_147_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164551"},{"key":"e_1_2_6_148_1","first-page":"2007","article-title":"Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture","volume":"32","author":"Weinhouse S","year":"1972","journal-title":"Cancer Res"},{"key":"e_1_2_6_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208719"},{"key":"e_1_2_6_150_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2317fje"},{"key":"e_1_2_6_151_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0605080104"},{"key":"e_1_2_6_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301866200"},{"key":"e_1_2_6_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1079605"},{"key":"e_1_2_6_154_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.1.e2"},{"key":"e_1_2_6_155_1","first-page":"I","article-title":"Mutational analysis of endothelial cell TGF\u2010\u03b2 receptor type II in plexiform lesions of patients with primary pulmonary hypertension","volume":"100","author":"Yeager ME","year":"1999","journal-title":"Circulation"},{"key":"e_1_2_6_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00847-X"},{"key":"e_1_2_6_157_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5912"},{"key":"e_1_2_6_158_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.F307"},{"key":"e_1_2_6_159_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.172360799"},{"key":"e_1_2_6_160_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3902"}],"container-title":["Comprehensive Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c090005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cphy.c090005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c090005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T01:22:17Z","timestamp":1740705737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cphy.c090005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"ISBN":["9780470650714"],"references-count":159,"alternative-id":["10.1002\/cphy.c090005","10.1002\/cphy"],"URL":"https:\/\/doi.org\/10.1002\/cphy.c090005","archive":["Portico"],"relation":{},"subject":[],"published":{"date-parts":[[2010,11]]}}}