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Depending on the cause or mechanism, central apneas may not be clinically significant, for example, those that occur normally at sleep onset. In contrast, central apneas occur in a number of disorders and result in pathophysiological consequences. Central apneas occur commonly in high\u2010altitude sojourn, disrupt sleep, and cause desaturation. Central sleep apnea also occurs in number of disorders across all age groups and both genders. Common causes of central sleep apnea in adults are congestive heart failure and chronic use of opioids to treat pain. Under such circumstances, diagnosis and treatment of central sleep apnea may improve quality of life, morbidity, and perhaps mortality. The mechanisms of central sleep apnea have been best studied in congestive heart failure and hypoxic conditions when there is increased CO<jats:sub>2<\/jats:sub>sensitivity below eupnea resulting in lowering eupneic PCO<jats:sub>2<\/jats:sub>below apneic threshold causing cessation of breathing until the PCO<jats:sub>2<\/jats:sub>rises above the apneic threshold when breathing resumes. In many other disorders, the mechanism of central sleep apnea (CSA) remains to be investigated. \u00a9 2013 American Physiological Society.<jats:italic>Compr Physiol<\/jats:italic>3:141\u2010163, 2013.<\/jats:p>","DOI":"10.1002\/cphy.c110057","type":"other","created":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T17:34:53Z","timestamp":1355160893000},"page":"141-163","source":"Crossref","is-referenced-by-count":142,"title":["Central Sleep Apnea"],"prefix":"10.1002","author":[{"given":"S.","family":"Javaheri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,1]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1130"},{"key":"e_1_2_6_3_1","first-page":"1287","article-title":"Nasal reflexes","volume":"62","author":"Angell James 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