{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:26:28Z","timestamp":1791289588166,"version":"4.3.0"},"edition-number":"1","reference-count":272,"publisher":"Wiley","isbn-type":[{"value":"9780470650714","type":"electronic"}],"license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The heart is adapted to utilize all classes of substrates to meet the high\u2010energy demand, and it tightly regulates its substrate utilization in response to environmental changes. Although fatty acids are known as the predominant fuel for the adult heart at resting stage, the heart switches its substrate preference toward glucose during stress conditions such as ischemia and pathological hypertrophy. Notably, increasing evidence suggests that the loss of metabolic flexibility associated with increased reliance on glucose utilization contribute to the development of cardiac dysfunction. The changes in glucose metabolism in hypertrophied hearts include altered glucose transport and increased glycolysis. Despite the role of glucose as an energy source, changes in other nonenergy producing pathways related to glucose metabolism, such as hexosamine biosynthetic pathway and pentose phosphate pathway, are also observed in the diseased hearts. This article summarizes the current knowledge regarding the regulation of glucose transporter expression and translocation in the heart during physiological and pathological conditions. It also discusses the signaling mechanisms governing glucose uptake in cardiomyocytes, as well as the changes of cardiac glucose metabolism under disease conditions. \u00a9 2016 American Physiological Society.<jats:italic>Compr Physiol<\/jats:italic>6:331\u2010351, 2016.<\/jats:p>","DOI":"10.1002\/cphy.c150016","type":"other","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T06:01:32Z","timestamp":1450159292000},"page":"331-351","source":"Crossref","is-referenced-by-count":163,"title":["Glucose Transporters in Cardiac Metabolism and Hypertrophy"],"prefix":"10.1002","author":[{"given":"Dan","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7605"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307740200"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.676"},{"key":"e_1_2_12_5_1","first-page":"H742","article-title":"Contribution of oxidative\u2010metabolism and glycolysis to Atp production in hypertrophied hearts","volume":"267","author":"Allard MF","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.78.63"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306782200"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3370461"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1073\/pnas.0510391103","article-title":"Muscle GLUT4 regulation by estrogen receptors ERbeta and ERalpha","volume":"103","author":"Barros RP","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025089"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03552-4"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","first-page":"5267","DOI":"10.1210\/endo.142.12.8555","article-title":"The endosomal compartment is an insulin\u2010sensitive recruitment site for GLUT4 and GLUT1 glucose transporters in cardiac myocytes","volume":"142","author":"Becker C","year":"2001","journal-title":"Endocrinology"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0213946"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.5.E1104"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"E420","DOI":"10.1152\/ajpendo.2001.280.3.E420","article-title":"Glucose metabolism in perfused mouse hearts overexpressing human GLUT\u20104 glucose transporter","volume":"280","author":"Belke DD","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.13.3.198"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn093"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.8.1429"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(85)90227-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1970.218.1.153"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0405"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm782"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7313"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.4.1135"},{"key":"e_1_2_12_25_1","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.1016\/S0021-9258(17)37547-6","article-title":"Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue\u2010specific regulation of GLUT4 expression by thyroid hormone","volume":"269","author":"Castello A","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M010144200"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1987.252.2.C163"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0116"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00171.2003"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85561-8"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.11.005"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.7.1092"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.3.C795"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3212"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595231"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13306"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/3253"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.4.578"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr055"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2004.05.014"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2003.11.021"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.281881"},{"issue":"3","key":"e_1_2_12_43_1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1042\/bj3500771","article-title":"Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar\u2010transport facilitators predominantly expressed in brain and leucocytes","volume":"350","author":"Doege H","year":"2000","journal-title":"Biochem J"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3590443"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.21.16275"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1181"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.4.467"},{"key":"e_1_2_12_48_1","first-page":"26","article-title":"Regulation of subcellular distribution of GLUT4 in cardiomyocytes: Rab4A reduces basal glucose transport and augments insulin responsiveness","volume":"108","author":"Dransfeld O","year":"2000","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401807"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00133-8"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.12.1407"},{"key":"e_1_2_12_52_1","doi-asserted-by":"crossref","first-page":"H1615","DOI":"10.1152\/ajpheart.1997.272.4.H1615","article-title":"Control of oxidative metabolism in volume\u2010overloaded rat hearts: Effect of propionyl\u2010L\u2010carnitine","volume":"272","author":"El Alaoui\u2010Talibi Z","year":"1997","journal-title":"Am J Physiol\u2010Heart C"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00775.2011"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3216"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31408"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0810"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401420"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0214080"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.4.C1204"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.11.7085"},{"key":"e_1_2_12_61_1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1152\/ajplegacy.1969.216.5.1026","article-title":"Changes in lactate dehydrogenase composition of hearts with right ventricular hypertrophy","volume":"216","author":"Fox AC","year":"1969","journal-title":"Am J Physiol"},{"key":"e_1_2_12_62_1","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1016\/S0021-9258(18)83106-4","article-title":"Cloning and characterization of the major insulin\u2010responsive glucose transporter expressed in human skeletal\u2010muscle and other insulin\u2010responsive tissues","volume":"264","author":"Fukumoto H","year":"1989","journal-title":"J Biol Chem"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-007-9123-5"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/200169a0"},{"key":"e_1_2_12_65_1","first-page":"H837","article-title":"Effects of diabetes on myocardial glucose transport system in rats: Implications for diabetic cardiomyopathy","volume":"264","author":"Garvey WT","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00717.x"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117823"},{"key":"e_1_2_12_68_1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1152\/jappl.1986.60.4.1268","article-title":"Intensity and duration effects of exercise on heart cAMP, phosphorylase, and glycogen","volume":"60","author":"Goldfarb AH","year":"1986","journal-title":"J Appl Physiol (1985)"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.16.9234"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.45.29530"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0629"},{"key":"e_1_2_12_72_1","first-page":"165","article-title":"The Kruppel\u2010like factor KLF15 regulates the insulin\u2010sensitive glucose transporter GLUT4","volume":"106","author":"Gray SJ","year":"2002","journal-title":"Circulation"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(98)00216-8"},{"key":"e_1_2_12_74_1","doi-asserted-by":"crossref","first-page":"18366","DOI":"10.1016\/S0021-9258(17)32316-5","article-title":"Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4","volume":"269","author":"Gulve EA","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2007.04.003"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2006.05.003"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.78.1.76"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.5.1679"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00721.2012"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.112.969576"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2536196100"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.8.1549"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.1.S82"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.24.070155.001231"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(02)00612-0"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2450313"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.8.3096"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.140"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2008.09.001"},{"key":"e_1_2_12_90_1","first-page":"173","article-title":"Glucose\u20106\u2010phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes","volume":"108","author":"Jain M","year":"2003","journal-title":"Circulation"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112605.43318.CA"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.21.8368"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.203661"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0539"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3201.092286"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00407.2001"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687680110090456"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1353"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(94)90007-8"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200198200"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)66976-0"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/377151a0"},{"key":"e_1_2_12_103_1","doi-asserted-by":"crossref","first-page":"13276","DOI":"10.1016\/S0021-9258(19)38295-X","article-title":"Human facilitative glucose transporters \u2010 isolation, functional\u2010characterization, and gene localization of Cdnas encoding an isoform (Glut5) expressed in small\u2010intestine, kidney, muscle, and adipose\u2010tissue and an unusual glucose transporter pseudogene\u2010like sequence (Glut6)","volume":"265","author":"Kayano T","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_12_104_1","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1016\/S0021-9258(19)37577-5","article-title":"Evidence for a family of human glucose transporter\u2010like proteins \u2010 sequence and gene localization of a protein expressed in fetal skeletal\u2010muscle and other tissues","volume":"263","author":"Kayano T","year":"1988","journal-title":"J Biol Chem"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.268128"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0469"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.4.H1345"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.18.12.6971"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950287"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0150"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.29.17513"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01056.2008"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503897200"},{"key":"e_1_2_12_114_1","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/S0021-9258(19)39979-X","article-title":"Phosphorylation of the glucose transporter in rat adipocytes. Identification of the intracellular domain at the carboxyl terminus as a target for phosphorylation in intact\u2010cells and in vitro","volume":"265","author":"Lawrence JC","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_12_115_1","first-page":"H1309","article-title":"Selective chronic regulation of GLUT1 and GLUT4 content by insulin, glucose, and lipid in rat cardiac muscle in vivo","volume":"273","author":"Laybutt DR","year":"1997","journal-title":"Am J Physiol"},{"key":"e_1_2_12_116_1","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1210\/endo.136.8.7628394","article-title":"Wortmannin inhibits the action of insulin but not that of okadaic acid in skeletal muscle: comparison with fat cells","volume":"136","author":"Le Marchand\u2010Brustel Y","year":"1995","journal-title":"Endocrinology"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.551457"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03655.x"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03276603"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(03)00007-2"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00507.2001"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.1.23"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00576.2006"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00234.2004"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00396.2003"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000034049.61181.F3"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3580517"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.11.3599-3609.2002"},{"key":"e_1_2_12_129_1","doi-asserted-by":"crossref","first-page":"28514","DOI":"10.1016\/S0021-9258(18)46957-8","article-title":"Myocyte enhancer factor\u20102 (Mef2) binding\u2010site is essential for C2c12 myotube\u2010specific expression of the rat Glut4 muscle\u2010adipose facilitative glucose\u2010transporter gene","volume":"269","author":"Liu ML","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49746-9"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2009"},{"key":"e_1_2_12_132_1","first-page":"103","article-title":"Use of transport mutants to examine the identity and expression of GLUT isoforms in rat cardiac myoblasts","volume":"41","author":"Lu Z","year":"1997","journal-title":"Biochem Mol Biol Int"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-09-0046"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2007.11.007"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.13.5817"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.691253"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00560-0"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0263-8"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.18.12567"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2670245"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.01.016"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.585984"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0699-8"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00742-9"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6457"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02137950"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00081-06"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061035098"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20050887"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C400180200"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(79)90437-1"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21480"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0602"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.9006"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2011.76.010868"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2003.12.022"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.5.1999"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306609200"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00457-8"},{"key":"e_1_2_12_160_1","first-page":"527","article-title":"Facilitative glucose transporters","volume":"912","author":"Mueckler M","journal-title":"Eur J Biochem"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3839598"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0250951"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000144292.69599.0c"},{"key":"e_1_2_12_164_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/ajplegacy.1970.219.4.1083","article-title":"Regulation of glycogenolysis in hearts: Effects of pressure development, glucose, and FFA","volume":"219","author":"Neely JR","year":"1970","journal-title":"Am J Physiol"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17412-6"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1159\/000395454"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.3.828"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001452200"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.62.1.1-34.1998"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(95)00019-4"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(98)00233-8"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1565"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000301"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.109967"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.189951"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.044"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(63)91500-9"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0930652"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(91)90012-M"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4901.100526"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000026392.80723.DC"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063122"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.273.6.H2876"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/11.2.172"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.1.C9"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01417-7"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00393-5"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.4.E692"},{"key":"e_1_2_12_190_1","first-page":"765","article-title":"Metabolic adaptation of the hypertrophied heart: Role of the malate\/aspartate and alpha\u2010glycerophosphate shuttles","volume":"100","author":"Rupert BE","year":"1999","journal-title":"Circulation"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.277.2.H643"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19297"},{"issue":"2","key":"e_1_2_12_193_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3420321","article-title":"In vitro analysis of the glucose\u2010transport system in GLUT4\u2010null skeletal muscle","volume":"342","author":"Ryder JW","year":"1999","journal-title":"Biochem J"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.37.5.527"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.047886"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.163865"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.03.001"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300063200"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.25.17626"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00472-3"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.5091"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)46778-0"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1080\/09687860500166143"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.91019.2008"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0990027"},{"key":"e_1_2_12_206_1","first-page":"H542","article-title":"Feeding and fasting determine postischemic glucose utilization in isolated working rat hearts","volume":"260","author":"Schneider CA","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1997.0394"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1998.274.3.C780"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.4.540"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.4.726"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.684"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199907223410406"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.1110"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.3.E562"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7815"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.67.6.1334"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668665"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25308"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00245-3"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00006.2004"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1096"},{"key":"e_1_2_12_222_1","first-page":"529","article-title":"The metabolic\u2010regulation and vesicular transport of Glut4, the major insulin\u2010responsive glucose\u2010transporter","volume":"16","author":"Stephens JM","year":"1995","journal-title":"Endocr Rev"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00171.2010"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0162"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00076.2008"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.15.10071"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.5.416"},{"key":"e_1_2_12_228_1","first-page":"II234","article-title":"Glucose transporter upregulation improves ischemic tolerance in hypertrophied failing heart","volume":"98","author":"Takeuchi K","year":"1998","journal-title":"Circulation"},{"key":"e_1_2_12_229_1","first-page":"76\u221216","article-title":"Nitric oxide stimulates glucose transport through insulin\u2010independent GLUT4 translocation in 3T3\u2010L1 adipocytes","volume":"941","author":"Tanaka T","journal-title":"Eur J Endocrinol"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0900"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00712.2009"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0052-7"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.24.2961"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4001.097183"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2012.07.001"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.775"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.2031"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00457.2001"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2005.02.004"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.16.4467"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03058-2"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(97)00220-4"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802005"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.20.12913"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.09.013"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0804"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00856-1"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)90651-M"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl032"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.014"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001907107"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0462fje"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164097"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(94)00211-8"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr555"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.2.E299"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2002763"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2002.7010"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303521200"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.832915"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162371799"},{"key":"e_1_2_12_262_1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1152\/jappl.1976.40.6.923","article-title":"Lactate\u2010dehydrogenase changes following several cardiac hypertrophic stresses","volume":"40","author":"York JW","year":"1976","journal-title":"J Appl Physiol"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.2.415"},{"key":"e_1_2_12_264_1","first-page":"251","article-title":"Proposed regulation of gene expression by glucose in rodent heart","volume":"1","author":"Young ME","year":"2007","journal-title":"Gene Regul Syst Bio"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04952.x"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00445.2011"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403773200"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00284464"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.5.1274"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179689"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00557.2007"},{"key":"e_1_2_12_272_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240038"},{"key":"e_1_2_12_273_1","first-page":"487","article-title":"Studies on the hexose monophosphate shunt in the myocardium during development of hypertrophy","volume":"1","author":"Zimmer HG","year":"1980","journal-title":"Adv Myocardiol"}],"container-title":["Comprehensive Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcphy.c150016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c150016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cphy.c150016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c150016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T02:21:00Z","timestamp":1718245260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cphy.c150016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"ISBN":["9780470650714"],"references-count":272,"alternative-id":["10.1002\/cphy.c150016","10.1002\/cphy"],"URL":"https:\/\/doi.org\/10.1002\/cphy.c150016","archive":["Portico"],"relation":{},"subject":[],"published":{"date-parts":[[2015,12,15]]}}}