{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:06:42Z","timestamp":1790125602330,"version":"4.0.1"},"edition-number":"1","reference-count":474,"publisher":"Wiley","isbn-type":[{"value":"9780470650714","type":"electronic"}],"license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1002\/cphy.c220012","type":"other","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T12:08:06Z","timestamp":1675080486000},"page":"4355-4386","source":"Crossref","is-referenced-by-count":17,"title":["Aging and Bone Metabolism"],"prefix":"10.1002","author":[{"given":"Robert J.","family":"Pignolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198702000-00038"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.12.082"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.06.030"},{"key":"e_1_2_12_5_1","first-page":"26","article-title":"Osteoporosis after spinal cord injury: Aetiology, effects and therapeutic approaches","volume":"21","author":"Abdelrahman S","year":"2021","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.038"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.510809"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20143576"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107695"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419900"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1941.02820220007002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13742"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00178.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.1883"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2012.102"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-007-0452-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70186-1"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119333"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041015"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3586"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1973.87"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2017.06.002"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/35083081"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4732-1"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200730010-00004"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200301000-00009"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041007"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4773"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370080073015"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.22-5-675"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.10.011"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4048"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021429"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.99.1.131"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp266"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.102.2.341"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110504"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-3-180"},{"key":"e_1_2_12_39_1","first-page":"45","article-title":"The impact of skeletal unloading on bone formation","volume":"16","author":"Bikle DD","year":"2003","journal-title":"Gravit Space Biol Bull"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3194"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100443"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2393"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0280-5"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1036475100"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2009.00535.x"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2018-10-1-4-14"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-018-0468-2"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-200411000-00003"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1627-9"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.4.3804"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.415507"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.014928"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2906"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90092-O"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.06.005"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0160-5"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(87)90015-9"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.10.010"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00633.x"},{"key":"e_1_2_12_60_1","first-page":"1289","article-title":"Development and validation of the Osteoporosis Risk Assessment Instrument to facilitate selection of women for bone densitometry","volume":"162","author":"Cadarette SM","year":"2000","journal-title":"CMAJ"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.286.1.57"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.003"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201804200"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0394-0"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.2.270"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2836"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080813"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.4.387"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09075-8"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.08.014"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3978"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2996"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.608158"},{"key":"e_1_2_12_74_1","first-page":"3","volume-title":"Fractures in the Elderly","author":"Chandra A","year":"2018"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1389"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02441186"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070207"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.051014"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1851"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1567"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5419-x"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1596-z"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.079"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1445"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4000"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115588"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24792"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060601"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldu042"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1426-z"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090704"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:17:1:21"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0060301"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02118"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-108-6-824"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12586"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0784-9"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.37753"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.11.012"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.21.6919"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.7.1243"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.6.785"},{"key":"e_1_2_12_103_1","first-page":"257","article-title":"Spinal cord injury\u2010related bone impairment and fractures: An update on epidemiology and physiopathological mechanisms","volume":"11","author":"Dionyssiotis Y","year":"2011","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh569"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2017.14.1.209"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.05.045"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1103"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002983"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.740571"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011685"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0533-1"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.04.024"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.9.3366"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317215"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90500-P"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1675-5"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2007.12.010"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091520203"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196605000-00001"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-2-825"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.4.716"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10942"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0417"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2892"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.89"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138347"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3729"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4385"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650081008"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22844-2"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2013.0766"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00199-6"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3298"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2300"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0173"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84137"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62214-3"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051248"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2016.06.003"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.1998.06198.x"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glu057"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.7.1317"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092190104"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556248"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.10119"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00412.x"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110307"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0067"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-09-457929"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-5-1288"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.03.010"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.7.629"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.6712"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240580312"},{"key":"e_1_2_12_155_1","first-page":"1087","article-title":"Peroxisome proliferator\u2010activated receptor\u2010gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells","volume":"50","author":"Gimble JM","year":"1996","journal-title":"Mol Pharmacol"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.015"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.218"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.686626"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.11.1833"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23619"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.4.716"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11075"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235249"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-18-0024"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.6-3-278"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100991"},{"key":"e_1_2_12_167_1","first-page":"398","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Harvey N","year":"2019"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.016"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/206489a0"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(65)90211-9"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(61)90192-6"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06218.x"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2015.0384"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.14694\/EdBook_AM.2014.34.e423"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.01.018"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3427"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3397"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.9.7131"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.162131.113"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110955"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.189"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.8.1318"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199507203330307"},{"key":"e_1_2_12_184_1","first-page":"1","article-title":"Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group","volume":"843","author":"Alexeeva P","year":"1994","journal-title":"World Health Organ Tech Rep Ser"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906266106"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10015"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1096-1132"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01156.x"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200074"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1918"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199211000-00009"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408617"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10334"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt046"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00616.x"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1621100"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-016-0297-0"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.44"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3868-0"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10574"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011513223894"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-2059-x"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.11.1215"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1997.12.11.1772"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-115-2-507"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1080\/10409238.2019.1570075"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5612"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2008.0130"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700030200"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4009-0"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-1964-3"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.319.7221.1334"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2425-5"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-124-3-1576"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00669.x"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12586"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5705"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118066"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.289"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls163"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2529"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.5.1522"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7736"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2266"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.03.008"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2005.07.009"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050916"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.10.025"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12923"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12597"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3038"},{"key":"e_1_2_12_233_1","first-page":"225","article-title":"Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury","volume":"37","author":"Kiratli BJ","year":"2000","journal-title":"J Rehabil Res Dev"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14969"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.01.041"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3787-0"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.4.721"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2365"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980170070"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.12.2281"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90111-2"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000133975.32559.6b"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22475"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090107"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2161"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1971610"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.039"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.144.11.4226"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X16670154"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36727"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0206"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00122a.x"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2017.11.003"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.05.012"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0127-y"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-139-2-200307150-00013"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12018-015-9200-2"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2016.03.003"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1038\/73542"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77716"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.935957"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413274200"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(92)90087-D"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.4.0437"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13148-011-0042-6"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2019.03.005"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.06.003"},{"key":"e_1_2_12_269_1","first-page":"37","article-title":"Development and validation of a simple questionnaire to facilitate identification of women likely to have low bone density","volume":"4","author":"Lydick E","year":"1998","journal-title":"Am J Manag Care"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03187467"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.05.010"},{"key":"e_1_2_12_272_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.2.115"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2113"},{"key":"e_1_2_12_274_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3104"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0354"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01673400"},{"key":"e_1_2_12_277_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.07.006"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.12.004"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524053586581"},{"key":"e_1_2_12_280_1","first-page":"276","article-title":"Age\u2010related changes in bone mass in the senescence\u2010accelerated mouse (SAM). SAM\u2010R\/3 and SAM\u2010P\/6 as new murine models for senile osteoporosis","volume":"125","author":"Matsushita M","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.12.3458"},{"key":"e_1_2_12_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.02.005"},{"key":"e_1_2_12_283_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2006.01.006"},{"key":"e_1_2_12_284_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080518"},{"key":"e_1_2_12_285_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.971"},{"key":"e_1_2_12_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.004"},{"key":"e_1_2_12_287_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197110000-00021"},{"key":"e_1_2_12_288_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.16.1825"},{"key":"e_1_2_12_289_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02547214"},{"key":"e_1_2_12_290_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2283"},{"key":"e_1_2_12_291_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2255"},{"key":"e_1_2_12_292_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000794"},{"key":"e_1_2_12_293_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00260"},{"key":"e_1_2_12_294_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872208311206030223"},{"key":"e_1_2_12_295_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2015.1026520"},{"key":"e_1_2_12_296_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.04.015"},{"key":"e_1_2_12_297_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00127.x"},{"key":"e_1_2_12_298_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.175.1.2315484"},{"key":"e_1_2_12_299_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3148"},{"key":"e_1_2_12_300_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.5.8156913"},{"key":"e_1_2_12_301_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4445"},{"key":"e_1_2_12_302_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200802105"},{"key":"e_1_2_12_303_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-005-0043-6"},{"key":"e_1_2_12_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.019"},{"key":"e_1_2_12_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.025"},{"key":"e_1_2_12_306_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-012-0402-0"},{"key":"e_1_2_12_307_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00401-X"},{"key":"e_1_2_12_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.03.041"},{"key":"e_1_2_12_309_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21319"},{"key":"e_1_2_12_310_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05875"},{"key":"e_1_2_12_311_1","first-page":"27","article-title":"Bone turnover and calcium metabolism during 20 days bed rest in young healthy males and females","volume":"616","author":"Nishimura Y","year":"1994","journal-title":"Acta Physiol Scand Suppl"},{"key":"e_1_2_12_312_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140775"},{"key":"e_1_2_12_313_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2211"},{"key":"e_1_2_12_314_1","first-page":"1496","article-title":"Principle of marginotomy in template synthesis of polynucleotides","volume":"201","author":"Olovnikov AM","year":"1971","journal-title":"Dokl Akad Nauk SSSR"},{"key":"e_1_2_12_315_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2480"},{"key":"e_1_2_12_316_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2152"},{"key":"e_1_2_12_317_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2778"},{"key":"e_1_2_12_318_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-002-1332-9"},{"key":"e_1_2_12_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-415853-5.00032-7"},{"key":"e_1_2_12_320_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-6-3313"},{"key":"e_1_2_12_321_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-128-3-1496"},{"key":"e_1_2_12_322_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.03.020"},{"key":"e_1_2_12_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2018.02.008"},{"key":"e_1_2_12_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1568-1637(02)00009-0"},{"key":"e_1_2_12_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2020.102956"},{"key":"e_1_2_12_326_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116110108"},{"key":"e_1_2_12_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/0221-8747(82)90002-9"},{"key":"e_1_2_12_328_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240550303"},{"key":"e_1_2_12_329_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100319"},{"key":"e_1_2_12_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(94)90893-1"},{"key":"e_1_2_12_331_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-009-9239-5"},{"key":"e_1_2_12_332_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93771"},{"key":"e_1_2_12_333_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72228-3_17"},{"key":"e_1_2_12_334_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10488"},{"key":"e_1_2_12_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.03.005"},{"key":"e_1_2_12_336_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-019-00504-2"},{"key":"e_1_2_12_337_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2007.00350.x"},{"key":"e_1_2_12_338_1","first-page":"792","article-title":"Anatomy of the bone marrow with special reference to the distribution of red marrow","volume":"2","author":"Piney A","year":"1922","journal-title":"Br Med J"},{"key":"e_1_2_12_339_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113125"},{"key":"e_1_2_12_340_1","first-page":"507","article-title":"1,25\u2010Dihydroxyvitamin D insufficiency accelerates age\u2010related bone loss by increasing oxidative stress and cell senescence","volume":"12","author":"Qiao W","year":"2020","journal-title":"Am J Transl Res"},{"key":"e_1_2_12_341_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(97)00276-7"},{"key":"e_1_2_12_342_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1208248109"},{"key":"e_1_2_12_343_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl116"},{"key":"e_1_2_12_344_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-008-9069-9"},{"key":"e_1_2_12_345_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.6.529"},{"key":"e_1_2_12_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(02)00864-5"},{"key":"e_1_2_12_347_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01593"},{"key":"e_1_2_12_348_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-8-200910200-00006"},{"key":"e_1_2_12_349_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60599-1"},{"key":"e_1_2_12_350_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.5.763"},{"key":"e_1_2_12_351_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040916"},{"key":"e_1_2_12_352_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071020"},{"key":"e_1_2_12_353_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.290635.116"},{"key":"e_1_2_12_354_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.446"},{"key":"e_1_2_12_355_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.20.2389"},{"key":"e_1_2_12_356_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1201862"},{"key":"e_1_2_12_357_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.08.002"},{"key":"e_1_2_12_358_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx026"},{"key":"e_1_2_12_359_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1909"},{"key":"e_1_2_12_360_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-021-00836-1"},{"key":"e_1_2_12_361_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i2.20"},{"key":"e_1_2_12_362_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05862"},{"key":"e_1_2_12_363_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503280102"},{"key":"e_1_2_12_364_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3976-5"},{"key":"e_1_2_12_365_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.5.892.892"},{"key":"e_1_2_12_366_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017487"},{"key":"e_1_2_12_367_1","doi-asserted-by":"publisher","DOI":"10.1038\/35088122"},{"key":"e_1_2_12_368_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.05.002"},{"key":"e_1_2_12_369_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/364890"},{"key":"e_1_2_12_370_1","doi-asserted-by":"publisher","DOI":"10.1038\/79683"},{"key":"e_1_2_12_371_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.349"},{"key":"e_1_2_12_372_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.08.004"},{"key":"e_1_2_12_373_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2003.10.001"},{"key":"e_1_2_12_374_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.02.023"},{"key":"e_1_2_12_375_1","doi-asserted-by":"publisher","DOI":"10.1080\/gye.16.3.245.250"},{"key":"e_1_2_12_376_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08706-8"},{"key":"e_1_2_12_377_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2389"},{"key":"e_1_2_12_378_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2605"},{"key":"e_1_2_12_379_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2015.06.013"},{"key":"e_1_2_12_380_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0602569103"},{"key":"e_1_2_12_381_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0602-592"},{"key":"e_1_2_12_382_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.01.014"},{"key":"e_1_2_12_383_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119701"},{"key":"e_1_2_12_384_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.08.049"},{"key":"e_1_2_12_385_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556310"},{"key":"e_1_2_12_386_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.9539"},{"key":"e_1_2_12_387_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019503"},{"key":"e_1_2_12_388_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.50B1.2"},{"key":"e_1_2_12_389_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1991"},{"key":"e_1_2_12_390_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.9.1613"},{"key":"e_1_2_12_391_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.3.2109"},{"key":"e_1_2_12_392_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.118"},{"key":"e_1_2_12_393_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041992"},{"key":"e_1_2_12_394_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.041"},{"key":"e_1_2_12_395_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-007-9016-2"},{"key":"e_1_2_12_396_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801197"},{"key":"e_1_2_12_397_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.284"},{"key":"e_1_2_12_398_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2604"},{"key":"e_1_2_12_399_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12124"},{"key":"e_1_2_12_400_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2016.03.001"},{"key":"e_1_2_12_401_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00185-G"},{"key":"e_1_2_12_402_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.051"},{"key":"e_1_2_12_403_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1176104"},{"key":"e_1_2_12_404_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.1.192"},{"key":"e_1_2_12_405_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.060904"},{"key":"e_1_2_12_406_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.12.015"},{"key":"e_1_2_12_407_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.137"},{"key":"e_1_2_12_408_1","first-page":"2","article-title":"FGF23\u2010Klotho axis in CKD","volume":"2","author":"Takashi Y","year":"2016","journal-title":"Renal Replacment Ther"},{"key":"e_1_2_12_409_1","first-page":"147","article-title":"Disuse osteoporosis","volume":"48","author":"Takata S","year":"2001","journal-title":"J Med Investig"},{"key":"e_1_2_12_410_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.38.3.109"},{"key":"e_1_2_12_411_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(96)00036-8"},{"key":"e_1_2_12_412_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(96)00068-X"},{"key":"e_1_2_12_413_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116179"},{"key":"e_1_2_12_414_1","first-page":"139","article-title":"Marrow adipose cells and hemopoiesis: An interpretative review","volume":"12","author":"Tavassoli M","year":"1984","journal-title":"Exp Hematol"},{"key":"e_1_2_12_415_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-4494-3_4"},{"key":"e_1_2_12_416_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-010-1300-8"},{"key":"e_1_2_12_417_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-016-4065-0"},{"key":"e_1_2_12_418_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-008-0627-x"},{"key":"e_1_2_12_419_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.01.025"},{"key":"e_1_2_12_420_1","first-page":"385","volume-title":"Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism","author":"Tran B","year":"2019"},{"key":"e_1_2_12_421_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409857112"},{"key":"e_1_2_12_422_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071164"},{"key":"e_1_2_12_423_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200000"},{"key":"e_1_2_12_424_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(93)90081-K"},{"key":"e_1_2_12_425_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.1995.140"},{"key":"e_1_2_12_426_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.60B3.681422"},{"key":"e_1_2_12_427_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3246"},{"key":"e_1_2_12_428_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980200084"},{"key":"e_1_2_12_429_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2014-1024"},{"key":"e_1_2_12_430_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1786"},{"key":"e_1_2_12_431_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00236-2"},{"key":"e_1_2_12_432_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8070686"},{"key":"e_1_2_12_433_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199904)32:4<272::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_12_434_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.19.10770"},{"key":"e_1_2_12_435_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3616-5"},{"key":"e_1_2_12_436_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-34255-4"},{"key":"e_1_2_12_437_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0455-8"},{"key":"e_1_2_12_438_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0887-1_8"},{"key":"e_1_2_12_439_1","first-page":"227","article-title":"Effects of microgravity on the gene expression and cellular functions of osteoblasts","volume":"16","author":"Wang B","year":"2003","journal-title":"Space Med Med Eng (Beijing)"},{"key":"e_1_2_12_440_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2019.0276"},{"key":"e_1_2_12_441_1","first-page":"2284","article-title":"Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved","volume":"55","author":"Wang E","year":"1995","journal-title":"Cancer Res"},{"key":"e_1_2_12_442_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197759060-00003"},{"key":"e_1_2_12_443_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00838.x"},{"key":"e_1_2_12_444_1","first-page":"1","article-title":"Cancer treatment\u2010induced accelerated aging in cancer survivors: Biology and assessment","volume":"13","author":"Wang S","year":"2021","journal-title":"Cancers (Basel)"},{"key":"e_1_2_12_445_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3961"},{"key":"e_1_2_12_446_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio239197a0"},{"key":"e_1_2_12_447_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85006"},{"key":"e_1_2_12_448_1","doi-asserted-by":"publisher","DOI":"10.1038\/492S12a"},{"key":"e_1_2_12_449_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031237"},{"key":"e_1_2_12_450_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.5.1873"},{"key":"e_1_2_12_451_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2599"},{"key":"e_1_2_12_452_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-013-0165-0"},{"key":"e_1_2_12_453_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408524"},{"key":"e_1_2_12_454_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.08.111"},{"key":"e_1_2_12_455_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.4.M203"},{"key":"e_1_2_12_456_1","doi-asserted-by":"publisher","DOI":"10.1016\/0273-1177(81)90254-4"},{"key":"e_1_2_12_457_1","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(86)90683-6"},{"key":"e_1_2_12_458_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12997"},{"key":"e_1_2_12_459_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515386112"},{"key":"e_1_2_12_460_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13095"},{"key":"e_1_2_12_461_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10315"},{"key":"e_1_2_12_462_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20367"},{"key":"e_1_2_12_463_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650100408"},{"key":"e_1_2_12_464_1","first-page":"1137","article-title":"Calcium metabolism and the menopause","volume":"60","author":"Young MM","year":"1967","journal-title":"Proc R Soc Med"},{"key":"e_1_2_12_465_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.05.010"},{"key":"e_1_2_12_466_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2001.16.8.1453"},{"key":"e_1_2_12_467_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302234"},{"key":"e_1_2_12_468_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2015.02.002"},{"key":"e_1_2_12_469_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1156"},{"key":"e_1_2_12_470_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60320-0"},{"key":"e_1_2_12_471_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900421"},{"key":"e_1_2_12_472_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1356"},{"key":"e_1_2_12_473_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6110"},{"key":"e_1_2_12_474_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14878"},{"key":"e_1_2_12_475_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7067984"}],"container-title":["Comprehensive Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c220012","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cphy.c220012","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cphy.c220012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T15:53:48Z","timestamp":1689868428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cphy.c220012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"ISBN":["9780470650714"],"references-count":474,"alternative-id":["10.1002\/cphy.c220012","10.1002\/cphy"],"URL":"https:\/\/doi.org\/10.1002\/cphy.c220012","archive":["Portico"],"relation":{},"subject":[],"published":{"date-parts":[[2023,1,30]]}}}