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In fact, hypertension is the second leading cause of kidney failure in the United States; it is a complex disease characterized by, leading to, and caused by renal dysfunction. It is well\u2010established that hypertensive renal damage is accompanied by mitochondrial damage and oxidative stress, which are differentially regulated and manifested along the nephron due to the diverse structure and functions of renal cells. This article provides a summary of the relevant knowledge of mitochondrial bioenergetics and metabolism, focuses on renal mitochondrial function, and discusses the evidence that has been accumulated regarding the role of epithelial mitochondrial bioenergetics in the development of renal tissue dysfunction in hypertension. \u00a9 2024 American Physiological Society.\n            <jats:italic>Compr Physiol<\/jats:italic>\n            14:5225\u20105242, 2024.\n          <\/jats:p>","DOI":"10.1002\/cphy.c220033","type":"other","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T15:07:58Z","timestamp":1703862478000},"page":"5225-5242","source":"Crossref","is-referenced-by-count":2,"title":["Renal Epithelial Mitochondria: Implications for Hypertensive Kidney Disease"],"prefix":"10.1002","author":[{"given":"Krisztian","family":"Stadler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria V.","family":"Ilatovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12927"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.11994"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00399.2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000019781.90630.0F"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092605"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37048"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.000533"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1215233"},{"key":"e_1_2_11_10_1","first-page":"F407","article-title":"Metabolic substrate utilization by rabbit proximal tubule. 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