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As a result, patients develop disfiguring white spots on the skin. This article discusses the first mouse model of vitiligo that develops epidermal depigmentation, similar to disease in human patients. To achieve epidermal depigmentation, mice are genetically engineered to retain melanocytes in the skin epidermis. Induction of disease occurs by adoptive transfer of melanocyte\u2010specific CD8<jats:sup>+<\/jats:sup> T cells into recipient mice and the subsequent activation of these T cells using a viral vector. Depigmentation of the epidermis occurs within 5 to 7 weeks in a patchy pattern similar to patients with vitiligo. This article describes the methods of vitiligo induction, quantification of lesion progression and regression, processing of the skin for detailed analysis, and how to use this model to inform clinical studies. \u00a9 2018 by John Wiley &amp; Sons, Inc.<\/jats:p>","DOI":"10.1002\/cpim.63","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T16:19:54Z","timestamp":1537892394000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mouse Model for Human Vitiligo"],"prefix":"10.1002","volume":"124","author":[{"given":"Rebecca L.","family":"Riding","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian M.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Massachusetts Medical School  Worcester Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.529"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2591"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1556\/EuJMI.2.2012.2.3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21426"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.11.1717"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33376"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480997"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1968.tb12282.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0108s73"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0106s73"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im0105s73"},{"key":"e_1_2_9_15_1","first-page":"16.17.1","article-title":"Generation of recombinant vaccinia viruses","volume":"43","author":"Earl P. 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