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Among these systems, carborane\u2010containing phthalocyanines (Pcs) are the most promising BNCT agents. Herein we report the new zinc (II) complex of the hexacationic Pc <jats:bold>6<\/jats:bold>, which has been obtained as iodide salt through quaternization of the neutral precursor with methyl iodide. Compound <jats:bold>6<\/jats:bold> was synthesized over a sequence of four steps. The complex, and its precursors as well, were characterized by a combination of spectroscopic techniques, and their structures assessed by <jats:sup>1<\/jats:sup>H, <jats:sup>13<\/jats:sup>C, <jats:sup>11<\/jats:sup>B, and two\u2010dimensional NMR spectroscopy experiments. Together with a marked tendency to aggregate, <jats:bold>6<\/jats:bold> showed appreciable solubility in water. Singlet oxygen quantum yield (<jats:italic>\u03a6<\/jats:italic><jats:sub>\u0394<\/jats:sub>) of 0.38, and fluorescence quantum yield (<jats:italic>\u03a6<\/jats:italic><jats:sub>F<\/jats:sub>) of 0.13 were obtained for <jats:bold>6<\/jats:bold> in a DMF solution. The complex proved to be very effective in enriching UMR\u2010106 cells with <jats:sup>10<\/jats:sup>B, showing very good performance even in case of very low concentrations exposure, i.\u2009e. 1\u2005ppm, that moreover resulted in a mild cytotoxic effect. Such a feature can be related to the polycationic nature of the complex, and hence to the well\u2010known propensity of positively charged species to enter the cellular membrane or to adhere to its external surface.<\/jats:p>","DOI":"10.1002\/cplu.201800560","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T21:41:00Z","timestamp":1546810860000},"page":"345-351","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["A Phthalocyanine\u2010<i>ortho<\/i>\u2010Carborane Conjugate for Boron Neutron Capture Therapy: Synthesis, Physicochemical Properties, and in vitro Tests"],"prefix":"10.1002","volume":"84","author":[{"given":"Ilg\u0131n","family":"Nar","sequence":"first","affiliation":[{"name":"Department of Chemistry Istanbul Technical University  34469, Maslak Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silva","family":"Bortolussi","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisica Universit\u00e0 of Pavia  Via Bassi 6 27100 Pavia Italy"},{"name":"Istituto Nazionale Di Fisica Nucleare (INFN) Unit of Pavia  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Postuma","sequence":"additional","affiliation":[{"name":"Dipartimento di Fisica Universit\u00e0 of Pavia  Via Bassi 6 27100 Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arma\u011fan","family":"Atsay","sequence":"additional","affiliation":[{"name":"Department of Chemistry Istanbul Technical University  34469, Maslak Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekin","family":"Berksun","sequence":"additional","affiliation":[{"name":"Department of Chemistry Istanbul Technical University  34469, Maslak Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Viola","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Roma Sapienza  Piazzale A. Moro 5 I-00185 Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Clinico-Chirurgiche Laboratorio di Chirurgia Sperimentale Universit\u00e0 di Pavia  Via Ferrata 9 27100 Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cansolino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Clinico-Chirurgiche Laboratorio di Chirurgia Sperimentale Universit\u00e0 di Pavia  Via Ferrata 9 27100 Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Scuola di Scienze Agrarie, Alimentari, Forestali e Ambientali (SAFE) Universit\u00e0 della Basilicata  Viale dell'Ateneo Lucano 10 85100 Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Donzello","sequence":"additional","affiliation":[{"name":"Dipartimento di Chimica Universit\u00e0 di Roma Sapienza  Piazzale A. 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