{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:38:57Z","timestamp":1764700737095,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Photodynamic therapy (PDT) is an approach to treating cancer and involves light\u2010induced activation of a photosensitizer that triggers the formation of reactive oxygen species (ROS) in targeted cells and subsequent cell death. Examples of photosensitizers are porphyrins, including the natural compound chlorophyll. These molecules can be delivered alone or co\u2010formulated with an agent, such as quantum dots (QDs), that is able to excite them through a fluorescence resonance energy transfer (FRET)\u2010based mechanism. We encapsulated a chlorophyllin copper complex and CdSe\/ZnS core\u2010shell QDs into biodegradable nanoparticles (NPs) composed of poly(lactide\u2010co\u2010glycolide) (PLGA), that allow modification with specific targeting ligands. When excited at 365\u2005nm, FRET occurs between co\u2010encapsulated QDs and chlorophyllin to result in the formation of ROS. This chlorophyllin\u2010QD coformulation allows generation of ROS both in an aqueous environment and in cells, thus confirming the potential of this formulation in PDT.<\/jats:p>","DOI":"10.1002\/cplu.201900342","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T05:40:13Z","timestamp":1566366013000},"page":"1653-1658","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Poly(Lactide\u2010Co\u2010Glycolide) Nanoparticles Co\u2010Loaded with Chlorophyllin and Quantum Dots as Photodynamic Therapy Agents"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4147-7457","authenticated-orcid":false,"given":"Marianna","family":"Galliani","sequence":"first","affiliation":[{"name":"NEST Scuola Normale Superiore  Piazza San Silvestro 12 56127 Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Signore","sequence":"additional","affiliation":[{"name":"NEST Scuola Normale Superiore  Piazza San Silvestro 12 56127 Pisa Italy"},{"name":"Fondazione Pisana per la Scienza  Via Ferruccio Giovannini 13 56017 San Giuliano Terme, Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_2_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.004"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201805246"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-008-0172-2"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/B915149B"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2010.12.006"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50087a010"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00547"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CC06133A"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200600157"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2016.08.094"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5596"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i21.5012"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/26\/5\/055102"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja070713i"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0386905"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp810324v"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01719"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR04853A"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b01664"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2018.1456027"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn700281b"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.8b00206"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9040652"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b12292"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.6b05052"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/17\/1\/022"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/la504558z"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl0347334"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2006.01.073"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00611"},{"key":"e_1_2_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2015.9"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.6b00701"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1248"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.201900342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cplu.201900342","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.201900342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T11:08:56Z","timestamp":1760440136000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.201900342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/cplu.201900342"],"URL":"https:\/\/doi.org\/10.1002\/cplu.201900342","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"type":"print","value":"2192-6506"},{"type":"electronic","value":"2192-6506"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"2019-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}