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The folded structures with C<jats:sub>10<\/jats:sub> H\u2010bonded pseudocycles were most preferred for dimer and tetramer of \u03b4Ac<jats:sub>5<\/jats:sub>a residues both in chloroform and water. However, for the hexameric Ac\u2010(\u03b4Ac<jats:sub>5<\/jats:sub>a)<jats:sub>6<\/jats:sub>\u2010NHMe, the mixed H<jats:sub>16\/14<\/jats:sub> helical structure was found to be most preferred in chloroform (populated at 68\u2009%), whereas the H<jats:sub>14<\/jats:sub> helical structure was the most dominant conformation in water (populated at 60\u2009%). The stability of the former was ascribed to the intrinsic conformational energy, whereas the solvation free energy was crucial to stabilize the latter. Pyrrolidine\u2010substituted analogues of the hexameric Ac\u2010(\u03b4Ac<jats:sub>5<\/jats:sub>a)<jats:sub>6<\/jats:sub>\u2010NHMe, with adjacent amine diads that are almost exactly one turn apart with two nitrogen atoms separated by ca. 5.5\u2005\u00c5, adopted helical structures. They are potential catalysts in nonpolar and polar solvents as they have similar structures to a helical 1\u2009:\u20092 \u03b1:\u03b2\u2010heptapeptide that exhibited good catalytic performance in the crossed aldol condensation.<\/jats:p>","DOI":"10.1002\/cplu.202000807","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T17:54:43Z","timestamp":1611856483000},"page":"533-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Conformational Preferences of Cyclopentane\u2010Based Oligo\u2010\u03b4\u2010peptides in the Gas Phase and in Solution"],"prefix":"10.1002","volume":"86","author":[{"given":"Hae Sook","family":"Park","sequence":"first","affiliation":[{"name":"Department of Nursing Cheju Halla University  Cheju 63092 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2200-8922","authenticated-orcid":false,"given":"Young Kee","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Chemistry Chungbuk National University, Cheongju  Chungbuk 28644 Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar960298r"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr990120t"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200490087"},{"key":"e_1_2_7_5_2","unstructured":"Foldamers: Structure Properties and Applications(Eds.: S. 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