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Whole\u2010cell\u2010based photosynthetic biohybrid systems (PBSs), an emerging interdisciplinary field, are considered as attractive biosynthetic platforms with great prospects in energy and environment, combining the superiorities of semiconductor materials with high energy conversion efficiency and living cells with distinguished biosynthetic capacity. This review presents a systematic discussion on the synthesis strategies of whole\u2010cell\u2010based PBSs that demonstrate a promising potential for applications in sustainable solar\u2010to\u2010chemical conversion, including light\u2010facilitated carbon dioxide reduction and biohydrogen production. 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