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The existing small\u2010molecule antiviral drugs are limited, due to their incidence of drug resistance and adverse side effects. As potential drugs, antiviral peptides have the benefits of high activity, high stability, and few side effects. Furthermore, the diversity of acquisition methods allows antiviral peptides to be quickly designed and yielded. The drug properties (such as high bioavailability and <jats:italic>in\u2005vivo<\/jats:italic> stability) of antiviral peptides can be improved by the developed modifications. Currently, two peptide antiviral drugs have been approved for the treatment of acquired immunodeficiency syndrome (AIDS). Many antiviral peptides have entered clinical trials for the treatment of diseases caused by viruses. In addition, new antiviral peptides are continuously being identified and validated against virus infections. Given the benefits of antiviral peptides, they will become major antiviral drugs to combat new outbreaks caused by unknown viruses in the future. This review provides an overview of recent developments in antiviral peptides with <jats:italic>in\u2005vivo<\/jats:italic> activity.<\/jats:p>","DOI":"10.1002\/cplu.202100351","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T22:18:19Z","timestamp":1636323499000},"page":"1547-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Antiviral Peptides with <i>in\u2005vivo<\/i> Activity: Development and Modes of Action"],"prefix":"10.1002","volume":"86","author":[{"given":"Bing","family":"Gao","sequence":"first","affiliation":[{"name":"School of Public Health Baotou Medical College, Baotou  31 Construction Road, Donghe District Baotou Inner Mongolia P. R. 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