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This work proposes a transition metal ion coordination\u2010based label\u2010free cysteine sensor with smartphone\u2010based square wave voltammetry sensing system for the point\u2010of\u2010care testing (POCT). In the sensing system, potential excitation and current measurements were accomplished by a miniaturized and integrated circuit board with a smartphone to wirelessly control the system via Bluetooth. The electrochemical currents changed with the cysteine concentrations ranging from 0\u2005\u03bcM to 200\u2005\u03bcM with a linearity correlation coefficient of 0.9915. The limit of detection was as low as 0.0149\u2005\u03bcM for cysteine. The smartphone\u2010based system provides an effective strategy for cysteine detection, and it can also serve as a promising portable sensing platform for the analysis of other small molecules.<\/jats:p>","DOI":"10.1002\/cplu.202200040","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T22:18:36Z","timestamp":1646691516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Label\u2010Free Sensing of Cysteine through Cadmium Ion Coordination: Smartphone\u2010Based Electrochemical Detection"],"prefix":"10.1002","volume":"87","author":[{"given":"Guang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Zhejiang University  Hangzhou 310027 P. R. 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