{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:24:40Z","timestamp":1790641480745,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21671068"],"award-info":[{"award-number":["21671068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of gallium(III) amide corroles including <jats:italic>meso<\/jats:italic>\u20105,15\u2010bis(pentafluorophenyl)\u201010\u2010(4\u2010Pyridinamide\u2010phenyl)corrole gallium (III) (<jats:bold>1\u2010Ga<\/jats:bold>), <jats:italic>meso<\/jats:italic>\u20105,15\u2010bis(pentafluorophenyl)\u201010\u2010(4\u2010Furamide\u2010phenyl)corrole gallium(III) (<jats:bold>2\u2010Ga<\/jats:bold>) and <jats:italic>meso<\/jats:italic>\u20105,15\u2010bis(pentafluorophenyl)\u201010\u2010(4\u2010Thiophenamide\u2010phenyl)corrole gallium(III) (<jats:bold>3\u2010Ga<\/jats:bold>) were synthesized. The interaction of these complexes with DNA and their photodynamic antitumor activities have been studied. UV spectra titration showed that these gallium(III) corroles interact with calf thymus DNA (CT\u2010DNA) through an external binding mode. All three gallium(III) corroles can effectively generate singlet oxygen under illumination and have good photostability. Among the three gallium(III) corroles, <jats:bold>2\u2010Ga<\/jats:bold> exhibited excellent photodynamic antitumor activity against the tested tumor cell lines under light irradiation (625\u00b12\u2005nm, 0.3\u2005mW\/cm<jats:sup>2<\/jats:sup>, 1.08\u2005J\/cm<jats:sup>2<\/jats:sup>). The best phototoxicity was observed by <jats:bold>2\u2010Ga<\/jats:bold> against HepG2 cells (IC<jats:sub>50<\/jats:sub>=6.3\u00b10.9), which is even better than temoporfin (IC<jats:sub>50<\/jats:sub>=8.4\u00b11.8). It could block HepG2 cells in the sub\u2010G0 phase and effectively induce apoptosis of HepG2 cells under 625\u2005nm light irradiation.<\/jats:p>","DOI":"10.1002\/cplu.202200413","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T09:35:43Z","timestamp":1672911343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gallium(III) Amide Corroles: DNA Interaction and Photodynamic Activity in Cancer Cells"],"prefix":"10.1002","volume":"88","author":[{"given":"Meng\u2010Yuan","family":"Li","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010He","family":"Cen","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Gui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1793-952X","authenticated-orcid":false,"given":"Hai\u2010Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong Province South China University of Technology  Guangzhou Guangdong 510640 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hui","family":"Liao","sequence":"additional","affiliation":[{"name":"Molecular Diagnosis and Treatment Center for Infectious Diseases Southern Medical University  Guangzhou Guangdong 510091 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Hao","family":"Zhong","sequence":"additional","affiliation":[{"name":"Guangzhou Quality Supervision and Testing Institute  Guangzhou Guangdong 5114471 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33587"},{"key":"e_1_2_8_3_1","volume":"13","author":"Algorri J. F.","year":"2021","journal-title":"Cancers"},{"key":"e_1_2_8_4_1","volume":"12","author":"Tan L.","year":"2022","journal-title":"Front. Oncol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00400"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037051"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/B915149B"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.201900176"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr5004198"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2013.06.028"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2017.08.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.09.013"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00590"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1142\/S1088424604000064"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2008.05.038"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106177"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201600633"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.103085"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-016-9879-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.12.025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.0c03016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2017.1281098"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.104974"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.04.077"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.042"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340613804488404"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-011-9634-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.12551"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-013-0632-2"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.03.060"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2021.111525"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja804665y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ04953K"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-3773(20001117)39:22<4048::AID-ANIE4048>3.0.CO;2-7"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2016.03.038"},{"key":"e_1_2_8_38_1","first-page":"1389","volume":"46","author":"Taniguchi M.","year":"2021","journal-title":"J. Photochem. Photobiol."},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2007.09.006"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00292a024"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2004.11.016"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2002)0750382DNILDO2.0.CO2"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-8545(02)00034-6"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2010.08.009"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202438"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb08240.x"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0pp00218f"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1980.tb02545.x"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.020"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2006.11.015"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2867"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2015.08.010"},{"key":"e_1_2_8_54_1","doi-asserted-by":"crossref","unstructured":"B. Kalyanaraman V. Darley-Usmar K.\u2005J. Davies P.\u2005A. Dennery H.\u2005J. Forman M.\u2005B. Grisham G.\u2005E. Mann K. Moore L.\u2005J. Roberts\u20052nd H. Ischiropoulos Free Radical Biol. Med.2012 52 1\u20136.","DOI":"10.1016\/j.freeradbiomed.2011.09.030"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022945107762"}],"updated-by":[{"DOI":"10.1002\/cplu.202500427","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000}}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202200413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cplu.202200413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202200413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:02:12Z","timestamp":1760374932000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.202200413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/cplu.202200413"],"URL":"https:\/\/doi.org\/10.1002\/cplu.202200413","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/cplu.202500427","asserted-by":"object"}]},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"value":"2192-6506","type":"print"},{"value":"2192-6506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2022-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200413"}}