{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:06:15Z","timestamp":1760403975510,"version":"build-2065373602"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52003224"],"award-info":[{"award-number":["52003224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current treatments for infections caused by multidrug\u2010resistant bacteria still remain challenging and therapeutic materials with high efficacy are of demand. Herein, a bactericidal nanocomposite was constructed by loading Roxarsone (ROX) onto nitrosylated mesoporous polydopamine (named mPDA@NO\u2010ROX). The designed nanocomposite exhibited considerable photothermal effect and controlled NO and ROX co\u2010delivery under the irradiation of near\u2010infrared laser (NIR) to achieve enhanced chemo\u2010photothermal antibacterial therapy. The <jats:italic>in\u2005vitro<\/jats:italic> antibacterial evaluation of the mPDA@NO\u2010ROX demonstrated the effective elimination of the Gram\u2010negative tetracycline\u2010resistant <jats:italic>Escherichia coil<\/jats:italic> and Gram\u2010positive methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> under mild NIR irradiation compared to merely ROX loaded unmodified mPDA, indicating the NO enhanced chemo\u2010photothermal therapy. In addition, the cytotoxicity experiments indicated that mPDA@NO\u2010ROX exhibited only 5\u2009% of hemolysis rate and high cell viability at 1\u2005mg\u2009mL<jats:sup>\u22121<\/jats:sup> against mammalian fibroblasts, suggesting the excellent biocompatibility. In conclusion, the mPDA@NO\u2010ROX could be a promising candidate for anti\u2010infection therapy of multidrug\u2010resistant bacteria.<\/jats:p>","DOI":"10.1002\/cplu.202300061","type":"journal-article","created":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T11:14:10Z","timestamp":1679483650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Roxarsone Delivery Nanocomposite Based on Nitrite\u2010Functionalized Mesoporous Polydopamine for Multidrug\u2010Resistant Bacterial Infections via Enhanced Chemo\u2010Photothermal Therapy"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-0277","authenticated-orcid":false,"given":"Zhecheng","family":"Kang","sequence":"first","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Wang","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture Department of Oral Implants School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-9601","authenticated-orcid":false,"given":"Tengjiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Frontiers Science Center for Flexible Electronics (FSCFE) Xi'an Institute of Flexible Electronics (IFE) &amp; Xi'an Institute of Biomedical Materials and Engineering (IBME) Northwestern Polytechnical University (NPU)  Xi'an Shaanxi 710072 P. R. China"},{"name":"Research &amp; Development Institute of Northwestern Polytechnical University in Shenzhen  Shenzhen Guangdong 518057 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,4]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.04.159"},{"key":"e_1_2_8_2_1","first-page":"1","volume":"2020","author":"Shang Z.","year":"2020","journal-title":"Research"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-0420-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-017-0187-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.055"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00318"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b17335"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.07.036"},{"key":"e_1_2_8_10_1","volume":"7","author":"Li Z.","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.03.023"},{"journal-title":"Polym. Chem.","year":"2016","author":"Holdsworth A.","key":"e_1_2_8_12_1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.136295"},{"journal-title":"Chem. Mater.","year":"2022","author":"Liu W.","key":"e_1_2_8_14_1"},{"journal-title":"Acta Biomater.","year":"2022","author":"Li G.","key":"e_1_2_8_15_1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201800510"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.11.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b06265"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.11.037"},{"key":"e_1_2_8_20_1","volume":"19","author":"Zhu M.","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7NR01857F"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201600150"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c12483"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TA02265K"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsusc.2022.152489"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122091"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202100738"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b03294"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201707440"},{"key":"e_1_2_8_30_1","volume":"10","author":"Qing G.","year":"2019","journal-title":"Nat. Commun."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm900896h"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b09871"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201204683"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b22136"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b02737"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.11.032"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2008.04.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.12.035"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.08.009"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202300061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202300061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T22:11:20Z","timestamp":1760393480000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.202300061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/cplu.202300061"],"URL":"https:\/\/doi.org\/10.1002\/cplu.202300061","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"type":"print","value":"2192-6506"},{"type":"electronic","value":"2192-6506"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"2023-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300061"}}