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The stability of the compounds in dichloromethane, DMSO, and DMSO\/culture media solutions was investigated by spectroscopy, cyclic voltammetry, and conductimetry, indicating the formation overtime of cationic monometallic [Au(HTSC)(DMSO)]<jats:sup>\u00b1<\/jats:sup> or [Au(HTSC)<jats:sub>2<\/jats:sub>]<jats:sup>\u00b1<\/jats:sup>, and\/or dimeric species. Neutral [{Au(TSC)}<jats:sub>2<\/jats:sub>] species were obtained from one of the compounds in dichlomethane\/n\u2010hexane solution and characterized by X\u2010ray crystallography revealing a Au\u2212Au bond, and deprotonated thiosemicarbazone (TSC). The cytotoxicity of the gold compounds and thiosemicarbazone ligands was evaluated against selected cancer cell lines and compared to that of Auranofin. Studies of the most stable, cytotoxic, and selective compound on a renal cancer cell line (Caki\u20101) demonstrated its relevant antimigratory and anti\u2010angiogenic properties, and preferential accumulation in the cell nuclei. 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