{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:51:38Z","timestamp":1790671898409,"version":"4.1.0"},"reference-count":88,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>PCl<jats:sub>3<\/jats:sub> and POCl<jats:sub>3<\/jats:sub> are the most important sources of phosphorus\u2010containing compounds. They are also used for large\u2010scale industrial productions. However, chemical reactions using the highly reactive PCl<jats:sub>3<\/jats:sub> and POCl<jats:sub>3<\/jats:sub> tend to result in overreactions. In addition, the reactions are usually exothermic and therefore their utilization sometimes involves significant risk. That is why some phosphorylating reagents with mild electrophilicity such as phosphoramidites have been developed. Although these mild electrophiles are very useful for the highly selective synthesis of organophosphorus compounds, problems persist: the high cost of the reagents, the generation of large amounts of waste, and the requirement of long reaction times and high temperatures. Continuous\u2010flow technology is one of the most promising solutions for these problems. In particular, precise control of reaction times and temperatures enabled by micro\u2010flow technology suppresses undesired reactions and allows the safe operation of exothermic reactions using highly reactive PCl<jats:sub>3<\/jats:sub> and POCl<jats:sub>3<\/jats:sub>. This Review describes recently reported reactions of PCl<jats:sub>3<\/jats:sub> and POCl<jats:sub>3<\/jats:sub> using continuous\u2010 and micro\u2010flow technologies.<\/jats:p>","DOI":"10.1002\/cplu.202300176","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T04:43:55Z","timestamp":1684903435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Continuous\u2010\/Micro\u2010Flow Reactions Using Highly Electrophilic PCl<sub>3<\/sub> and POCl<sub>3<\/sub>"],"prefix":"10.1002","volume":"88","author":[{"given":"Hiroshi","family":"Kitamura","sequence":"first","affiliation":[{"name":"Department of Basic Medicinal Sciences Graduate School of Pharmaceutical Sciences Nagoya University Furo-cho, Chikusa-ku  Nagoya 464-8601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6836-4180","authenticated-orcid":false,"given":"Shinichiro","family":"Fuse","sequence":"additional","affiliation":[{"name":"Department of Basic Medicinal Sciences Graduate School of Pharmaceutical Sciences Nagoya University Furo-cho, Chikusa-ku  Nagoya 464-8601 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/227561a0"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/312315a0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.175.4023.720"},{"key":"e_1_2_6_4_1","unstructured":"\u00a0"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0075-7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00283-5"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00162-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2050"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC02705K"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201500147"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.201500147"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar2002864"},{"key":"e_1_2_6_12_1","unstructured":"\u00a0"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar400071v"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41557-022-00913-4"},{"key":"e_1_2_6_15_1","unstructured":"\u00a0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","unstructured":"J.-i. 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