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The premature release of H<jats:sub>2<\/jats:sub>S from small molecule donors and the difficulty in controlling its spatio\u2010temporal distribution are the major challenges during these efforts. Hence the development of appropriate carriers that can release this gasotransmitter along with the therapeutic entity of interest in a controlled manner has high significance. In this regard, this report presents a novel drug delivery system from oxanorbornane\u2010based synthetic lipids that carries a H<jats:sub>2<\/jats:sub>S\u2010releasing 1,2\u2010dithiole\u20103\u2010thione moiety as part of the head group. 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