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Herein, a V\u2010shaped aggregation\u2010induced emission (AIE) active Schiff base SDANA was introduced for the fluorescent turn\u2010on detection of Oflx. The Schiff base SDANA was synthesized by condensing 4,4\u2032\u2010sulfonyldianiline with two equivalents of 2\u2010hydroxy\u20101\u2010naphthaldehyde. The nearly non\u2010fluorescent SDANA in DMSO showed strong orange emission with the increase in HEPES buffer (H\n                    <jats:sub>2<\/jats:sub>\n                    O, 10\u2005mM, pH\u20057.4) fractions in DMSO from 70\u2009%\u201395\u2009% due to the combined effects of AIE and ESIPT. The DLS and SEM analyses were performed to complement the formation of self\u2010aggregates of SDANA. With the addition of Oflx, the fluorescence emission of AIE luminogen (AIEgen) SDANA (\u03bb\n                    <jats:sub>em<\/jats:sub>\n                    =575\u2005nm, \u03bb\n                    <jats:sub>ex<\/jats:sub>\n                    =400\u2005nm) was blue\u2010shifted and enhanced at 530\u2005nm. The interactions of Oflx over the surface of SDANA aggregates disrupted the intramolecular charge transfer and aggregation morphology of SDANA, which gave a distinct fluorescence response to detect Oflx. The detection limit for Oflx was estimated as 0.81\u2005\u03bcM, and the developed probe AIEgen SDANA was applied for the quantification of Oflx in human blood serum.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202400537","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T05:26:47Z","timestamp":1726896407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["4,4\u2032\u2010Sulfonyldianiline Derived Aggregation\u2010Induced Emission Luminogen for the Detection of Ofloxacin"],"prefix":"10.1002","volume":"90","author":[{"given":"Dhvani A.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Chemistry Sardar Vallabhbhai National Institute Technology  Surat, Gujarat 395007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thangaraj","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sathyabama Institute of Science and Technology  Chennai 600119 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bigyan R.","family":"Jali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Veer Surendra Sai University of Technology  Burla, Sambalpur, Odisha 768018 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-5310","authenticated-orcid":false,"given":"Suban K.","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sardar Vallabhbhai National Institute Technology  Surat, Gujarat 395007 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Health Organization (2019). 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