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Carbidopa has shown the ability to inhibit the MDA\u2010MB\u2010231\u2005cell line, a highly aggressive triple\u2010negative human breast adenocarcinoma, by inducing reductive stress. The metal complex of carbidopa with zinc (ZnCarbi) was designed to modify carbidopa's structure and exhibited increased cytotoxicity against MDA\u2010MB\u2010231 cells. Interestingly, ZnCarbi selectively targets certain cancer cells, showing no impact on the viability of normal HEK293 (human embryonic kidney) cells or other cancer cell lines like A549 (human lung adenocarcinoma), LM3 (murine breast adenocarcinoma), or HCT116 (human colon cancer). Treatment with carbidopa and ZnCarbi induces reductive stress, decreases ROS levels, increases the GSH\/GSSG ratio, and protects cells from H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced death. Both compounds also cause mitochondrial damage, leading to cell death, and exhibit antimetastatic effects by inhibiting cell migration and invasion of MDA\u2010MB\u2010231 cells. Interaction studies with bovine serum albumin showed moderate binding through hydrophobic association. Overall, ZnCarbi demonstrates enhanced anticancer properties compared to carbidopa alone, highlighting its potential as an anticancer and antimetastatic compound.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202400596","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T11:28:36Z","timestamp":1734953316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Carbidopa and ZnCarbidopa Induce Reductive Stress in MDA\u2010MB\u2010231 Cells"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2678-2808","authenticated-orcid":false,"given":"Agustin B.","family":"Actis Dato","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Inorg\u00e1nica (CEQUINOR-CONICET-UNLP- Asoc CICPBA)- Departamento de Qu\u00edmica-Facultad de Ciencias Exactas Universidad Nacional de La Plata  Boulevard 120 entre\u200560 y 64, C.C.962- (B1900AVV) 1900 La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-7450","authenticated-orcid":false,"given":"Luciana G.","family":"Naso","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Inorg\u00e1nica (CEQUINOR-CONICET-UNLP- Asoc CICPBA)- Departamento de Qu\u00edmica-Facultad de Ciencias Exactas Universidad Nacional de La Plata  Boulevard 120 entre\u200560 y 64, C.C.962- (B1900AVV) 1900 La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-6979","authenticated-orcid":false,"given":"Valeria R.","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"CIC\u2013CONICET-UNLP Facultad de M\u00e9dicas Universidad Nacional de La Plata  60 y 120 1900 La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6343-5170","authenticated-orcid":false,"given":"Evelina G.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Inorg\u00e1nica (CEQUINOR-CONICET-UNLP- Asoc CICPBA)- Departamento de Qu\u00edmica-Facultad de Ciencias Exactas Universidad Nacional de La Plata  Boulevard 120 entre\u200560 y 64, C.C.962- (B1900AVV) 1900 La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-5873","authenticated-orcid":false,"given":"Patricia A. 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