{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:19:11Z","timestamp":1791065951959,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:00:00Z","timestamp":1731628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Quercetin, a natural flavonoid with antioxidant, anti\u2010inflammatory, and anticancer properties, faces limitations in clinical application due to its poor solubility and bioavailability. This study presents a novel delivery system utilizing a combination of polyoxyethylene (100) stearyl ether and folic acid to enhance quercetin's effectiveness. We developed folate\u2010conjugated polyoxyethylene (100) stearyl ether\u2010coated liposomes (FA\u2010Brij\u2010LPs) to leverage the unique properties of polyoxyethylene (100) stearyl ether in conjunction with folic acid for targeted delivery. The FA\u2010Brij\u2010LPs were prepared using the thin\u2010film hydration method and characterized for their physicochemical properties, including size, zeta potential, and drug loading capacity. The optimized FA\u2010Brij\u2010LPs exhibited a mean particle size of 147.57\u2005nm, a zeta potential of 32.20\u2005mV, and a drug loading capacity of 9.33\u2009%.\n                    <jats:italic>In vitro<\/jats:italic>\n                    studies demonstrated sustained quercetin release and significantly enhanced cellular uptake compared to free quercetin. The Resazurin cell viability assay further revealed superior anticancer efficacy of FA\u2010Brij\u2010LPs. This innovative approach underscores the effectiveness of combining polyoxyethylene (100) stearyl ether with folic acid in enhancing quercetin delivery and its potential applications in cancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202400600","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T03:50:01Z","timestamp":1729655401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Advancing Liposomal Coating Approaches for Improved Anticancer Drug Delivery"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-802X","authenticated-orcid":false,"given":"Ngoc","family":"Thuy Trang Le","sequence":"first","affiliation":[{"name":"Institute of Applied Materials Science Vietnam Academy of Science and Technology  1B TL29 Thanh Loc Ward, District 12 Ho Chi Minh Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-2938","authenticated-orcid":false,"given":"Anh\u2010Minh","family":"Nguyen\u2010Huu","sequence":"additional","affiliation":[{"name":"Institute of Applied Materials Science Vietnam Academy of Science and Technology  1B TL29 Thanh Loc Ward, District 12 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3501-7390","authenticated-orcid":false,"given":"Dai","family":"Hai Nguyen","sequence":"additional","affiliation":[{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Ha Noi Vietnam"},{"name":"Institute of Chemical Technology Vietnam Academy of Science and Technology  1A TL29 Thanh Loc Ward, District 12 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuu","family":"Khoa Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Applied Materials Science Vietnam Academy of Science and Technology  1B TL29 Thanh Loc Ward, District 12 Ho Chi Minh Vietnam"},{"name":"Graduate University of Science and Technology Vietnam Academy of Science and Technology  18 Hoang Quoc Viet, Cau Giay Ha Noi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8825387"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.52855"},{"key":"e_1_2_7_4_1","unstructured":"\u00a0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00289-022-04091-8"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.37107"},{"key":"e_1_2_7_7_1","unstructured":"\u00a0"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2022.100257"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/08839115211053926"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1201\/9781351057639-3"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202005332"},{"key":"e_1_2_7_12_1","unstructured":"\u00a0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.2174\/1567201817666200415112657"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9389934"},{"key":"e_1_2_7_15_1","unstructured":"\u00a0"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/app.49858"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1557\/s43578-021-00105-9"},{"key":"e_1_2_7_18_1","unstructured":"\u00a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36862"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.4c00334"},{"key":"e_1_2_7_21_1","unstructured":"\u00a0"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.12.011"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112317"},{"key":"e_1_2_7_24_1","first-page":"1","author":"Fidan Y.","year":"2023","journal-title":"J. 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