{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:41:05Z","timestamp":1791326465340,"version":"4.3.1"},"reference-count":87,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metal\u2010Organic Frameworks (MOFs) are an emerging class of solid\u2010state materials comprising inorganic elements and organic molecules. These hybrid materials are widely recognized for their diverse properties, rendering them indispensable in the field of organic synthesis, material science and the pharmaceutical industry. Although the traditional batch methods for MOFs synthesis are well\u2010developed, they often struggle with reproducibility, scalability and environmental issues. However, the development of continuous flow techniques has emerged as a promising alternative, offering more efficient mass and heat transfer, precise reaction control, greater potential for automation, improved safety, and reduced environmental impact. This review primarily focuses on advanced continuous flow synthesis of MOFs incorporating techniques such as air flow, spray drying, microwave, micro\u2010droplets, supercritical carbon dioxide, and ultrasound. Additionally, the recent advancements in applying MOFs as heterogeneous catalysts for various organic transformations under continuous flow conditions are discussed, categorized by the type of bond formation, including C\u2212H bond formation (hydrogen reduction), C\u2212C bond formation, and C\u2212O bond formation.<\/jats:p>","DOI":"10.1002\/cplu.202400634","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:25:02Z","timestamp":1734956702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Continuous Flow Synthesis and Applications of Metal\u2010Organic Frameworks: Advances and Innovations"],"prefix":"10.1002","volume":"90","author":[{"given":"Rashed","family":"Rahman","sequence":"first","affiliation":[{"name":"School of Science Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"},{"name":"Green Pharmaceutical Engineering Research Centre Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazal","family":"Malik","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"},{"name":"Green Pharmaceutical Engineering Research Centre Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaw","family":"Min Hein","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"},{"name":"Green Pharmaceutical Engineering Research Centre Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8647-5418","authenticated-orcid":false,"given":"Junrong","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"},{"name":"Green Pharmaceutical Engineering Research Centre Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8904-5050","authenticated-orcid":false,"given":"Hengzhi","family":"You","sequence":"additional","affiliation":[{"name":"School of Science Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"},{"name":"Green Pharmaceutical Engineering Research Centre Harbin Institute of Technology (Shenzhen)  Shenzhen 518055 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1443-3453","authenticated-orcid":false,"given":"Yuxiang","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen) Shenzhen Campus of Sun Yat-sen University  Shenzhen 518107 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.137607"},{"key":"e_1_2_8_2_1","volume":"18","author":"Yang F.","year":"2022","journal-title":"Small"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enchem.2023.100101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.2c00270"},{"key":"e_1_2_8_5_1","first-page":"1","volume":"13","author":"Bag P. P.","year":"2020","journal-title":"Eng. Sci."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enchem.2021.100067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215300"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2021.213845"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2020.114897"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CC04190A"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fuel.2023.130541"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2021.04.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c05310"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00113"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2019.09.054"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","unstructured":"J. McGinty N. Yazdanpanah C. Price J.\u2005H. ter\u2005Horst J. Sefcik inThe Handbook of Continuous Crystallization CHAPTER 1: Nucleation and Crystal Growth in Continuous Crystallization(Eds.: N. Yazdanpanah; Z. K. Nagy) 2020 pp. 1\u201350.","DOI":"10.1039\/9781788013581-00001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtsust.2021.100104"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6GC03413F"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","unstructured":"Y. Qiu Y. Chen G.\u2005G.Z.\u2005Zhang L. Yu R.\u2005V.\u2005Mantri inDeveloping Solid Oral Dosage Forms:Second Edition Elsevier 2017 pp. 1127\u20131160.","DOI":"10.1016\/B978-0-12-802447-8.00056-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.9b05395"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2021.800820"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.0c00133"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1246\/cl.160651"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RE00065G"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7GC03132G"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0gc00823k"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pssa.201330070"},{"key":"e_1_2_8_28_1","doi-asserted-by":"crossref","unstructured":"S. Horikoshi N. Serpone Microwaves in Nanoparticle Synthesis: Fundamentals and Applications Wiley 2013 pp. 1\u20131352.","DOI":"10.1002\/9783527648122.ch1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CE00848D"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201505139"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7CE00867H"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2018.09.011"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.9b00170"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2020.03.001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2020.123278"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seppur.2024.129723"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/2213335610666221208163107"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja4039642"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c22153"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2022.112005"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2021.101246"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2017.03.002"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2015.08.071"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc46049e"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/am4029872"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-023-02944-8"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10853-023-08342-5"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TA09932B"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.cgd.3c00022"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.supflu.2017.12.033"},{"key":"e_1_2_8_51_1","doi-asserted-by":"crossref","unstructured":"N. Aoki A. Sato H. Sasaki A.\u2005A. Litwinowicz G.Seong T. Aida D. Hojo S. Takami T. Adschiri J. Supercrit. Flu.2016 161\u2013166.","DOI":"10.1016\/j.supflu.2015.11.015"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0961-9534(03)00016-3"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijhydene.2019.10.070"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.0c01429"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.138053"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cc33920j"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112369"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC07953J"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2CY00875K"},{"key":"e_1_2_8_60_1","volume":"8","author":"Swamy A.","year":"2023","journal-title":"Chem. Select"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c03607"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1259835"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NR03634K"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2021.106113"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201000354"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.9b01001"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.0c00177"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c03607"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja990031y"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.9b07891"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7TA09036F"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b06459"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c07450"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b01753"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b06239"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b04886"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570193X19666220104093837"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc100076k"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06745"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/ecsoc-24-08359"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.3699"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/cssc.201700318"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9GC03299A"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.9b02829"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0200769"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1039\/b207506g"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2012.02.027"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202400634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T20:35:49Z","timestamp":1764362149000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.202400634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,3]]},"references-count":87,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cplu.202400634"],"URL":"https:\/\/doi.org\/10.1002\/cplu.202400634","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"value":"2192-6506","type":"print"},{"value":"2192-6506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,3]]},"assertion":[{"value":"2024-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202400634"}}