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To achieve these goals, dispersions of TiO\n                    <jats:sub>2<\/jats:sub>\n                    particles incorporating three different formulations of biomimetically synthesized silica xerogels were tested. Emphasis has been given to the role of single and dual solvents employed. Microbiocide capability was induced by benzalkonium chloride along with silver nanoparticles. Particular emphasis should be given to hyperbranched poly(ethylene imine) multifunctional roles. Spontaneous mineralization of silver ions is realized in the dendritic cavities. The same polymer acts as a matrix that interacts with the hydrogen bonding network of orthosilicic acid directing and facilitating gel formation. Furthermore, it contributes to both hydrophilicity and antimicrobial properties. Gel formation and subsequent drying occur in the pores of the impregnated TiO\n                    <jats:sub>2<\/jats:sub>\n                    substrate. The resistance of the leathers to fungal and bacterial infections and biofilm formation was assessed against\n                    <jats:italic>Klebsiella Pneumoniae, Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . The affinity to water was proved by the contact angle method. The proposed treatment is a prospective environmentally friendly replacement to the standard finishing process of medical leathers.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202400648","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T22:15:41Z","timestamp":1738188941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Solvent Effect on Antimicrobial Hydrophilic Xerogel Coating of Medicinal Leathers in Simulated Industrial Finishing Process"],"prefix":"10.1002","volume":"90","author":[{"given":"Theofanis","family":"Bompotis","sequence":"first","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Karastergiou","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Giannakopoulos","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos P.","family":"Favvas","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Arvanitopoulou","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Arvanitopoulos","sequence":"additional","affiliation":[{"name":"DARVICHEM Alexandrou  Papagou 5 18233 Agios Ioannis Rentis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labros","family":"Arvanitopoulos","sequence":"additional","affiliation":[{"name":"DARVICHEM Alexandrou  Papagou 5 18233 Agios Ioannis Rentis Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Kythreoti","sequence":"additional","affiliation":[{"name":"Institute of Bioscience and Applications NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"},{"name":"Department of Science and Mathematics School of Liberal Arts and Sciences The American College of Greece, Deree  Gravias 6 15342 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Vardavoulias","sequence":"additional","affiliation":[{"name":"PYROGENESIS S.A., Technological Park 1  Athinon Avenue 19500 Attica Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios A.","family":"Giannakoudakis","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry Maria Curie-Sk\u0142odowska University  Maria Curie-Sk\u0142odowska Sq. 3 20-031 Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Castellsagu\u00e9s","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Universitat de Barcelona 08036 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Maria","family":"Soto Gonz\u00e1lez.","sequence":"additional","affiliation":[{"name":"Barcelona Institute for Global Health (ISGlobal)  Universitat de Barcelona 08036 Barcelona Spain"},{"name":"CIBER Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III  28029 Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-3361","authenticated-orcid":false,"given":"Michael","family":"Arkas","sequence":"additional","affiliation":[{"name":"Institute of Nanoscience Nanotechnology, NCSR \u201cDemokritos\u201d  Patriarchou Gregoriou Street 15310 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,21]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"128","volume-title":"Experimental determination of stone tool uses: A microwear analysis. 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