{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:42:54Z","timestamp":1767919374707,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["202203021212002"],"award-info":[{"award-number":["202203021212002"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>The direct liquid\u2010phase oxidative C\u2500H functionalization of hydrocarbons using molecular oxygen represents an attractive sustainable approach for ketone synthesis, offering advantages in atom economy and environmental compatibility. However, existing catalytic systems often require harsh conditions or suffer from overoxidation issues, limiting their practical applicability. Herein, a highly efficient and selective catalytic system is reported for benzylic C\u2500H oxidation of alkyl aromatics under exceptionally mild conditions, employing a synergistic combination of trivalent cobalt acetylacetonate [Co(acac)<jats:sub>3<\/jats:sub>] and N\u2010hydroxyphthalimide (NHPI) in neutral media. This catalytic protocol achieves outstanding ketone yields up to 99% with &gt;99% selectivity at 70\u2009\u00b0C under atmospheric oxygen pressure. The system demonstrates remarkable substrate scope tolerance, accommodating various functional groups while maintaining excellent efficiency (up to 99% conversion and selectivity). Notably, the methodology has been successfully scaled to multigram production of acetophenone without compromising yield and selectivity. Comprehensive mechanistic studies, including <jats:sup>18<\/jats:sup>O<jats:sub>2<\/jats:sub> isotopic labeling experiment, unequivocally establish a two\u2010step reaction pathway proceeding through a 1\u2010phenylethanol intermediate. This work provides significant advances in sustainable oxidation catalysis by combining operational simplicity with exceptional selectivity under mild conditions, offering promising potential for industrial implementation.<\/jats:p>","DOI":"10.1002\/cplu.202500166","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:55:11Z","timestamp":1746500111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neutral Aerobic Oxidation of Alkyl Aromatics via Synergistic Co<sup>III<\/sup>\/NHPI Catalysis"],"prefix":"10.1002","volume":"90","author":[{"given":"Qian\u2010Xia","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences  Taiyuan 030001 P. R. 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