{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:15:34Z","timestamp":1776212134884,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,10,9]]},"abstract":"<jats:p>\n                    A methodology for assessing the association constants of a molecular host binding a\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010enriched gaseous guest, that is,\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    , using NMR spectroscopic titrations is described. The method relies on injecting the gaseous guest into the headspace of a gas\u2010tight NMR tube filled with the host's solution. The fraction of the gas dissolved in the liquid solution is quantified via\n                    <jats:sup>13<\/jats:sup>\n                    C NMR spectroscopy using the Electronic Reference To Access In\u2009Vivo Concentrations technique without requiring assumptions based on Henry's law. By subsequently recording the\n                    <jats:sup>1<\/jats:sup>\n                    H NMR spectrum of the solution mixture, the relationship between the chemical shift changes experienced by the proton signals of the host and the precise concentration of the added gaseous guest can be established. Repeating the process over a range of incremental gas concentrations allows for generating the binding isotherm curve. The nonlinear computer fit of the data to a suitable theoretical binding model returns the values of the association constant and the complexation\u2010induced shift for the protons in the complex. The method is applied to the assessment of the association constant values of the complexes formed from the interaction of\n                    <jats:sup>13<\/jats:sup>\n                    CO\n                    <jats:sub>2<\/jats:sub>\n                    with two macrocyclic receptors.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202500209","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:37:57Z","timestamp":1756215477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the Association Constant of the CO\n                    <sub>2<\/sub>\n                    @CB[6] Complex Combining\n                    <sup>1<\/sup>\n                    H and\n                    <sup>13<\/sup>\n                    C NMR Spectroscopic Titrations"],"prefix":"10.1002","volume":"90","author":[{"given":"Leonard","family":"Curet","sequence":"first","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdel","family":"Khoukh","sequence":"additional","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Lafargue Dit","family":"Hauret","sequence":"additional","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Martinez\u2010Belmonte","sequence":"additional","affiliation":[{"name":"Institute of Chemical Research of Catalonia (ICIQ) Avda. Pa\u00efsos Catalans  16 43007 Tarragona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Ehrenfeld","sequence":"additional","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Begu\u00e9","sequence":"additional","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Billon","sequence":"additional","affiliation":[{"name":"Universite de Pau et Pays de l\u2019Adour IPREM UMR 5254 Technopole H\u00e9lioparc  2 avenue du Pr\u00e9sident Pierre Angot 64053 PAU CEDEX 09 France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Palomares","sequence":"additional","affiliation":[{"name":"Institute of Chemical Research of Catalonia (ICIQ) Avda. 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