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Herein, triblock polymers composed of pyropheophorbide a photosensitizer (PPa), polyethylene glycol, and phospholipid are synthesized. These triblock polymers, driven by hydrophilic\u2013hydrophobic interactions, spontaneously fold into an amphiphilic structure and further self\u2010assemble into nanomicelles. This novel nanomicelle, termed nanoPPa, provides a stable, nonpolar microenvironment for photosensitizer molecules, thereby enhancing photodynamic energy efficiency by minimizing energy loss from molecular collisions and self\u2010aggregation. Compared to the photosensitizer PPa alone, nanoPPa exhibits a remarkable fivefold increase in singlet oxygen generation, accompanied by a substantial boost in phototoxicity. Simultaneously, an increased fluorescence emission is observed. These enhancements in phototoxicity and fluorescence signify the potential of nanoPPa for dual applications in photodynamic therapy (PDT) and photodynamic imaging (PDI). The fabrication of this nanostructure is proposed as a versatile strategy to improve the application of photosensitizers and enhance therapeutic outcomes.<\/jats:p>","DOI":"10.1002\/cplu.202500232","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T10:01:16Z","timestamp":1757066476000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improved Photocytotoxicity Based on Triblock Polymer\u2010Derived Nanostructure"],"prefix":"10.1002","volume":"90","author":[{"given":"Zeman","family":"Shao","sequence":"first","affiliation":[{"name":"Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices Huaiyin Institute of Technology  Huai\u2019an Jiangsu 223003 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanghui","family":"Xu","sequence":"additional","affiliation":[{"name":"Provincial Engineering Research Center for Biomedical 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