{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:45:47Z","timestamp":1762929947246,"version":"3.45.0"},"reference-count":38,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,11,10]]},"abstract":"<jats:p>Two beta\u2010cyclodextrins (\u03b2\u2010CD) modified with 2\u2010hydroxyethyl\u20101,2,3\u2010triazole or hydroxymethyl\u20101,2,3\u2010triazole groups are synthesized utilizing copper catalyzed 1,3\u2010Huisgen click cycloaddition reaction. A simple electrochemical purification process is employed to remove unwanted copper from the desired products affording up to 88% removal in 10 h. Physicochemical analysis of both purified modified \u03b2\u2010CDs (Mod\u03b2\u2010CDs) reveales marked differences caused just by the additional methyl group, not only between their physicochemical properties (such as melting point and hydrophilicity) but also in their capabilities to self\u2010assemble forming aggregates at relatively low concentrations, which demonstrates to be efficient structures for encapsulating hydrophobic molecules, as it is demonstrated here with curcumin. These Mod\u03b2\u2010CDs spontaneously formes aggregates that presented globular shapes with diameters between 100 and 400\u2009nm (as verified by dynamic light scattering and atomic force microscopy analyses). Such type of aggregates could expand the notion of capturing larger molecules within these Mod\u03b2\u2010CD\u2010based structures (by not being confined just to the size of the \u03b2\u2010CD toroidal cavity), thus increasing their performances to solubilize in a more efficient way hydrophobic compounds in aqueous solutions. This promising data suggests this simple modification could improve the ability of \u03b2\u2010CD\u2010based compounds to capture other large molecules of interest for the remediation of contaminated sites or for medicinal\/pharmaceutical purposes.<\/jats:p>","DOI":"10.1002\/cplu.202500490","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T11:10:22Z","timestamp":1758539422000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Properties and Encapsulation Capabilities of Beta\u2010Cyclodextrin Modified with (Hydroxymethyl or 2\u2010Hydroxyethyl)\u20101,2,3\u2010Triazole Purified Electrochemically"],"prefix":"10.1002","volume":"90","author":[{"given":"Marcos","family":"Toniolo","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada del Litoral (IQAL) Universidad Nacional del Litoral\u2014CONICET  Santiago del Estero 2829 Santa Fe 3000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia G.","family":"Adam","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada del Litoral (IQAL) Universidad Nacional del Litoral\u2014CONICET  Santiago del Estero 2829 Santa Fe 3000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7457-1541","authenticated-orcid":false,"given":"M. Virginia","family":"Bravo","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada del Litoral (IQAL) Universidad Nacional del Litoral\u2014CONICET  Santiago del Estero 2829 Santa Fe 3000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3365-9074","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Aplicada del Litoral (IQAL) Universidad Nacional del Litoral\u2014CONICET  Santiago del Estero 2829 Santa Fe 3000 Argentina"},{"name":"Programa de Electroqu\u00edmica Aplicada e Ingenier\u00eda Electroqu\u00edmica (PRELINE) Facultad de Ingenier\u00eda Qu\u00edmica Universidad Nacional del Litoral  Santiago del Estero 2829 Santa Fe 3000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/js950534b"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.125599"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2023.121500"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.112758"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2034359"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3797\/scipharm.0808-05"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature16185"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656816"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(98)00092-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7797-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2015.11.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.127528"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.09.016"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.2610140304"},{"key":"e_1_2_8_16_1","first-page":"289","volume":"24","author":"Kido N.","year":"2009","journal-title":"Cancer Biother. Radiopharm."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1355-y"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/mz500590d"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.5b00046"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.15227\/orgsyn.077.0225"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0RA02574G"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200800728"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2018.02.002"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2013.08.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.200300449"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-013-0023-5"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.201901823"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201003221"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2022.153638"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02761h"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.02.074"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.02.037"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micron.2007.06.017"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01053637"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.126621"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0111965"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/C39850001814"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.201500225"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-013-0023-5"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202500490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:42:12Z","timestamp":1762929732000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.202500490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,22]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,10]]}},"alternative-id":["10.1002\/cplu.202500490"],"URL":"https:\/\/doi.org\/10.1002\/cplu.202500490","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"type":"print","value":"2192-6506"},{"type":"electronic","value":"2192-6506"}],"subject":[],"published":{"date-parts":[[2025,9,22]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500490"}}