{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T01:55:14Z","timestamp":1774230914822,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy","doi-asserted-by":"publisher","award":["R&D\u2010021\u22122018"],"award-info":[{"award-number":["R&D\u2010021\u22122018"]}],"id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006593","name":"Board of Research in Nuclear Sciences","doi-asserted-by":"publisher","award":["58\/14\/05\/2021\u2010BRNS\/37093"],"award-info":[{"award-number":["58\/14\/05\/2021\u2010BRNS\/37093"]}],"id":[{"id":"10.13039\/501100006593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2025,12,10]]},"abstract":"<jats:p>\n                    Benzothiazoles, including the cationic thioflavin T and its variants, are of immense interest because of their therapeutic potential and applications as biomolecular fluorescence probes. This study investigates the photophysics of an interesting benzothiazole derivative, TEG\u2010BTA\u20102, that combines a neutral thioflavin T type of moiety (BTA\u20102) with a tetraethylene glycol chain (TEG). Unlike thioflavin T, TEG\u2010BTA\u20102 is highly fluorescent and shows multiple prototropic transformations. Monoprotonated TEG\u2010BTA\u20102 is found to exist in two isomeric forms, each having characteristic absorption, emission, and fluorescence lifetimes. Furthermore, TEG\u2010BTA\u20102 shows strong affinity toward the cavitands\n                    <jats:italic>\u03b1<\/jats:italic>\n                    \u2010,\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010, and\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010cyclodextrins (CDs). The binding constants of TEG\u2010BTA\u20102 with the cavitands are considerably higher than that of thioflavin T, which is attributed to its neutral charge and favorable hydrophobic\/H\u2010bonding interactions provided by the TEG chain. Interestingly, it is found that the size of the macrocyclic cavity plays a pivotal role in controlling the fluorescence response of TEG\u2010BTA\u20102 due to formation of complexes with different stoichiometries. In contrast to the fluorescence enhancement observed with\n                    <jats:italic>\u03b1<\/jats:italic>\n                    CD and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    CD, the interaction of TEG\u2010BTA\u20102 with\n                    <jats:italic>\u03b3<\/jats:italic>\n                    CD leads to fluorescence quenching. These results provide valuable insights for development of thioflavin T\u2010inspired benzothiazole molecules as fluorescent markers and diagnostic agents.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202500513","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T18:23:24Z","timestamp":1761071004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["On the Photophysics and Contrasting Cavitand Binding of a Fluorescent Amphiphilic Benzothiazole"],"prefix":"10.1002","volume":"90","author":[{"given":"Ananya","family":"Bera","sequence":"first","affiliation":[{"name":"Radiation &amp; Photochemistry Division Bhabha Atomic Research Centre  Mumbai 400 085 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit N.","family":"Ketkar","sequence":"additional","affiliation":[{"name":"Department of Speciality Chemicals Technology Institute of Chemical Technology  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