{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:42:08Z","timestamp":1777239728223,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:p>\n                    In this study, we have presented a green and efficient protocol for the synthesis of diverse perimidine derivatives by employing deep eutectic solvents (DESs)\u2014acting as reaction media and catalyst. Markedly, this method not only eliminates the need for hazardous solvents and expensive catalysts but also works under operationally mild and eco\u2010friendly conditions while affording the anticipated products in good\u2010to\u2010excellent yields. Among the various tested eutectic mixtures, the combination of choline chloride (ChCl) with\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2032\u2010dimethylurea (DMU) showed the best efficiency and reproducibility with aldehydic partners while reacting with 1,8\u2010diaminonapthalene. On the other front, a melt of the DMU and\n                    <jats:italic>L<\/jats:italic>\n                    \u2010(+)\u2010tartaric acid afforded worthy results between ketones and 1,8\u2010diaminonapthalene. Pleasingly, by using this DESs\u2010mediated green methodology, we have assembled a variety of useful functionalized perimidines including four bioactive molecules (\n                    <jats:bold>5b\u2013e<\/jats:bold>\n                    ) and an anionic sensor (\n                    <jats:bold>5a<\/jats:bold>\n                    ). Thus, the prepared perimidines were characterized by means of standard nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The melting points for all compounds besides the IR spectral data for the novel molecules have also been revealed. Additionally, the structures of two novel derivatives (\n                    <jats:bold>9e\u2013f<\/jats:bold>\n                    ) were unequivocally ascertained using single crystal X\u2010ray diffraction analysis. Herewith, we have also reported the preliminary absorption (\u03bb\n                    <jats:sub>max<\/jats:sub>\n                    at 234\u2009nm) and emission properties of the synthesized compounds. Remarkably, this method was applied to a large\u2010scale synthesis besides the catalytic efficiency was also checked thrice without much loss in the product yield\u2014making this method attractive from the industrial perspective.\n                  <\/jats:p>","DOI":"10.1002\/cplu.202500648","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T11:14:27Z","timestamp":1776338067000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis of Pharmacologically Important Perimidines using Eco\u2010Friendly Deep Eutectic Solvents"],"prefix":"10.1002","volume":"91","author":[{"given":"Lubna","family":"Khan","sequence":"first","affiliation":[{"name":"Organic and Supramolecular Functional Materials Research Laboratory Department of Chemistry Jamia Millia Islamia  Okhla New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3567-7690","authenticated-orcid":false,"given":"Rashid","family":"Ali","sequence":"additional","affiliation":[{"name":"Organic and Supramolecular Functional Materials Research Laboratory Department of Chemistry Jamia Millia Islamia  Okhla New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2022.100606"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570430505"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111601"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/18741045-v16-e2202280"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c04506"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10406638.2021.2019803"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00322a035"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272824999200622113807"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-020-00307-5"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1747519820919625"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2016.1165254"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/zaac.201100561"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2015.02.091"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2014.10.080"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.941"},{"key":"e_1_2_10_17_1","first-page":"555","article-title":"Zeolite Catalyzed Efficient Synthesis of Perimidines at Room Temperature","volume":"33","author":"Mobinikhaledi A.","year":"2009","journal-title":"Turkish Journal of Chemistry"},{"key":"e_1_2_10_18_1","first-page":"353","article-title":"Molecular Iodine Catalyzed Synthesis of some Biologically Active Dihydroperimidines","volume":"45","author":"Mobinikhaledi A.","year":"2013","journal-title":"Bulgarian Chemical Communications"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15533170902784961"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2015.10.004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/00304948.2023.2186652"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-013-1428-1"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164-013-1501-9"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4OB01306A"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/M1587"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10698-004-2783-1"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470988305"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780198506980.001.0001"},{"key":"e_1_2_10_29_1","volume-title":"In Heterocyclic Chemistry - New Perspectives","author":"Khan L.","year":"2024"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272826666220126165925"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2025.122136"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b01724"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5c01075"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CP53456A"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300162p"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp510420h"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272827666230427101210"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC01515J"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1OB01618K"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061-025-00525-9"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00293"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2022.100338"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272825666210111111313"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202103104"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2018.4877"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.202001109"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol302034r"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2021.1878225"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/je5001796"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jced.3c00706"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40544-021-0575-4"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2022.139320"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2025.128095"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-022-01427-w"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA00543G"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cc47121g"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904-018-1028-z"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2014.08.024"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202500648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cplu.202500648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.202500648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:25:22Z","timestamp":1777238722000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.202500648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/cplu.202500648"],"URL":"https:\/\/doi.org\/10.1002\/cplu.202500648","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"value":"2192-6506","type":"print"},{"value":"2192-6506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202500648"}}