{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:26:08Z","timestamp":1789777568280,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disease with typical pathological features including \u03b2\u2010amyloid (A\u03b2) plaques. Achieving early and accurate detection of cerebral A\u03b2 aggregates is essential for timely intervention in AD, but the process is challenging. To address the lack of high\u2010sensitivity and high signal\u2010to\u2010noise ratio near\u2010infrared imaging tools for the early pathological detection of A\u03b2, we designed and synthesized two BODIPY\u2010quinoline\u2010based fluorescent probes,\n                    <jats:bold>BQ\u20101<\/jats:bold>\n                    and\n                    <jats:bold>BQ\u20102<\/jats:bold>\n                    , for targeting A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    aggregates.\n                    <jats:bold>BQ\u20101<\/jats:bold>\n                    showed high affinity (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>D<\/jats:sub>\n                    \u2009=\u200948.81\u2009nM), high sensitivity (LOD\u2009=\u200952\u2009nM), and high signal\u2010to\u2010noise ratio (189.5\u2010fold) for A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    aggregates. Based on the twisted intramolecular charge transfer (TICT) mechanism,\n                    <jats:bold>BQ\u20101<\/jats:bold>\n                    showed near\u2010infrared fluorescence emission (\n                    <jats:italic>\u03bb<\/jats:italic>\n                    <jats:sub>ex<\/jats:sub>\n                    \/\n                    <jats:italic>\u03bb<\/jats:italic>\n                    <jats:sub>em<\/jats:sub>\n                    \u2009=\u2009612\/669\u2009nm, Stokes shift 57\u2009nm) after binding to A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    aggregates, which showed good optical properties. Cell imaging experiments showed that\n                    <jats:bold>BQ\u20101<\/jats:bold>\n                    could label A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    aggregates in PC12 cells with high selectivity and low cytotoxicity. This study demonstrates that\n                    <jats:bold>BQ\u20101<\/jats:bold>\n                    is a near\u2010infrared (NIR) fluorescent probe with excellent performance and provides a potential tool for early pathological imaging diagnosis of AD.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70196","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:55:25Z","timestamp":1782395725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, Synthesis, and Performance Characterization of BODIPY\u2010Based NIR Probes for A\u03b2\n                    <sub>42<\/sub>\n                    Aggregate Detection"],"prefix":"10.1002","volume":"91","author":[{"given":"Jiaoru","family":"Chen","sequence":"first","affiliation":[{"name":"Center of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Ding","sequence":"additional","affiliation":[{"name":"Center of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dezhong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Center of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5904-6164","authenticated-orcid":false,"given":"Jinpei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry China Pharmaceutical University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-6317","authenticated-orcid":false,"given":"Huibin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center of Drug Discovery State Key Laboratory of Natural Medicines China Pharmaceutical University  Nanjing P. R. 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