{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:23Z","timestamp":1790319563939,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    In this study, novel phosphorus\u2010containing and pH\u2010responsive poly[2\u2010(methacryloyloxy)ethyl phosphate] (PMOEP) microgels were successfully synthesized for the first time via emulsion polymerization using a PBzDMA\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010PMEMA diblock copolymer steric stabilizer. Their performance was systematically compared with poly[2\u2010(diethylamino)ethyl methacrylate] (PDEA) microgels cross\u2010linked with multifunctional phosphorus agents (DMEP, TMEP) and EGDMA. Dynamic light scattering (DLS) analysis demonstrated that while EGDMA\u2010cross\u2010linked PDEA microgels exhibited a volumetric swelling capacity of 3330%, PMOEP microgels reached a significantly lower swelling ratio of 594% under identical conditions. Electrokinetic and DLS measurements revealed high colloidal stability across pH 3\u201312. The electrophoretic mobility (\n                    <jats:italic>\u03bc<\/jats:italic>\n                    <jats:sub>e<\/jats:sub>\n                    ) remained consistently negative, shifting from \u22121.20\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    \u2009m\n                    <jats:sup>2\u2009<\/jats:sup>\n                    V\n                    <jats:sup>\u22121\u2009<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    at pH 3.3 to a maximum magnitude of \u22122.49\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    \u2009m\n                    <jats:sup>2\u2009<\/jats:sup>\n                    V\n                    <jats:sup>\u22121\u2009<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    at pH 11.2, providing a robust evaluation of surface charge without model\u2010dependent conversions for swollen soft structures. Furthermore, PMOEP microgels displayed multi\u2010stimuli responsiveness to pH, temperature, and salt concentration. Evaluated using Ibuprofen as a model drug under physiological conditions (pH 7.4, 37\u2009\u00b0C), in vitro release showed a biphasic sustained profile, reaching 100% cumulative release over 113\u2009h. These findings demonstrate that potentially biocompatible, phosphonic acid\u2010functionalized microgels represent a versatile platform for advanced controlled drug delivery systems.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70232","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:10:28Z","timestamp":1787695828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Synthesis of Multi\u2010Stimuli Responsive PMOEP Microgels: Phosphorus\u2010Based Platform for Controlled Drug Delivery"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8844-2513","authenticated-orcid":false,"given":"Yasemin","family":"Samav","sequence":"first","affiliation":[{"name":"Department of Chemistry and Chemical Process Technologies Vocational School of Higher Education Bilecik \u015eeyh Edebali University  Bilecik Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-6129","authenticated-orcid":false,"given":"Cansel","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Eski\u015fehir Osmangazi University  Eski\u015fehir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-46915-4_11"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm2004803"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201600644"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813932-5.00005-4"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201801077"},{"key":"e_1_2_10_7_1","volume-title":"Encyclopedia of Polymer Science and Technology","author":"Weil E. D.","year":"2002"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/9781782624523","volume-title":"Phosphorus\u2010Based Polymers: From Synthesis to Applications","author":"Monge S.","year":"2014"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY01872F"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2017.07.095"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.05.160"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/1539445X.2016.1150294"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3144\/expresspolymlett.2016.23"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2018.11.020"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano10010131"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12221-008-0105-2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2015.11.002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.04.032"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/app8071145"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2019.121772"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2011.12.031"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED-D-16-00232"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12221-017-7628-3"},{"issue":"2","key":"e_1_2_10_24_1","first-page":"71","article-title":"Effect of Thermal Cycling on the Shear Bond Strength of Different Orthodontic Adhesives to Enamel","volume":"58","author":"Silvab F. S.","year":"2017","journal-title":"Revista Portuguesa de Estomatologia, Medicina Dent\u00e1ria e Cirurgia Maxilofacial"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.9b00910"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/b512106j"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201902710"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-8686(98)00071-2"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-8686(99)00023-8"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(97)00173-0"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2006.12.008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200501043"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2012.08.053"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/B406727D"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2018.06.047"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.383"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.024"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.11.012"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42114-019-00082-y"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.05.047"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.08.062"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.34016"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.41195"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB02046H"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570-015-0799-4"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6622(86)80274-8"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00203-4"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.008"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(98)00035-0"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-9140(03)00095-X"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2011.02.022"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(69)90032-5"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2018.08.011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.161"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856204322977184"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2007.06.061"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22530"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0032-3861(01)00066-0"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma001550k"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13233-020-8148-3"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.22760"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.porgcoat.2004.10.001"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2005.11.018"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40843-018-9357-9"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.powtec.2013.07.018"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2009.11.015"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SM02236J"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/pola.24112"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/la035921c"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0py00054j"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma300048m"}],"container-title":["ChemPlusChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.70232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cplu.70232","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cplu.70232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:09:12Z","timestamp":1790316552000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cplu.70232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cplu.70232"],"URL":"https:\/\/doi.org\/10.1002\/cplu.70232","archive":["Portico"],"relation":{},"ISSN":["2192-6506","2192-6506"],"issn-type":[{"value":"2192-6506","type":"print"},{"value":"2192-6506","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2026-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70232"}}