{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:21Z","timestamp":1790319561933,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    This study aims to ascertain the phytochemical composition of the essential oil obtained from\n                    <jats:italic>Achillea biebersteinii<\/jats:italic>\n                    Afan. flowers, to validate its antioxidant and antifungal properties, and to identify the active components implicated in the antifungal mechanisms by molecular docking analysis. The 46 different compounds were identified by GC\u2013MS analysis, 14 of which were present at concentrations greater than 1%. The main compounds are eucalyptol (21.84%),\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010Chrysanthenol (17.86%), camphor (15.29%), (\u2212)\u2010\u03b1\u2010Pinene (6.14%),\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010Chrysanthenyl acetate (5.80%). The DPPH\u2022 and ABTS\n                    <jats:sup>+<\/jats:sup>\n                    radical scavenging effects of the essential oil were shown be moderately active, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 11.76 and 3.45\u2009mg\/mL. As a result of antifungal activity,\n                    <jats:italic>A. biebersteinii<\/jats:italic>\n                    flower essential oil demonstrated substantial activity on\n                    <jats:italic>Candida<\/jats:italic>\n                    species. The MIC of the essential oil against\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    was 0.937\u2009\u00b5L\/mL, while against other\n                    <jats:italic>Candida<\/jats:italic>\n                    species it was 3.75\u2009\u00b5L\/mL. Molecular docking was carried out to determine the effects of compounds in the essential oil of\n                    <jats:italic>A. biebersteinii<\/jats:italic>\n                    flowers on antifungal activity. In silico studies showed that \u03b1\u2010Terpineol and\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010Pinocarveol, with docking scores, were two of the components with the highest affinity against both\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    and\n                    <jats:italic>C. parapsilosis<\/jats:italic>\n                    and were determined to be potential antifungal compounds.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70246","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:14:41Z","timestamp":1790115281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vitro and In Silico Analysis of Antioxidant and Antifungal Activity of Essential Oil From\n                    <i>Achillea biebersteinii<\/i>"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-6160","authenticated-orcid":false,"given":"Zehra","family":"Torun","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Inonu University  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8655-2716","authenticated-orcid":false,"given":"Tuba","family":"Unver","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology Faculty of Pharmacy Inonu University  Malatya Turkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-7196","authenticated-orcid":false,"given":"M. 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