{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:58:17Z","timestamp":1790470697714,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005621","name":"Kasetsart University Research and Development Institute","doi-asserted-by":"publisher","award":["YF(KU)17.66"],"award-info":[{"award-number":["YF(KU)17.66"]}],"id":[{"id":"10.13039\/501100005621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A670604"],"award-info":[{"award-number":["N42A670604"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014795","name":"Center of Excellence for Innovation in Chemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Cannabidiol (CBD) nanoformulations have gained increasing interest in pharmaceutical development. However, comprehensive analytical methods for complex nanoformulated samples remain underexplored. In this study, an HPLC\u2013UV method coupled with QuEChERS extraction was developed and validated according to ICH guidelines for nanoformulated CBD analysis. Representative matrices included spray\u2010dried CBD\u2010loaded lipid nanoparticle (CBD\u2010LNP) powder and Dulbecco's modified Eagle medium (DMEM) for cell\u2010based assays. The method showed excellent linearity (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009&gt;\u20090.999) over 1\u2013100\u2009\u00b5g\/mL for both matrices, with minimal matrix effects. The LODs were 0.17 and 0.15\u2009\u00b5g\/mL, and the LOQs were 0.51 and 0.46\u2009\u00b5g\/mL for powder and DMEM, respectively. CBD recoveries were above 90% for both powder and DMEM. Intra\u2010 and inter\u2010day precision (%RSD) were below 2.8% and 7.8%, respectively. The validated method was applied to stability testing of nanoformulated CBD products containing 3% and 5% CBD, showing that 25\u2009\u00b0C was the optimal storage temperature over 6 months. A cellular uptake study also revealed higher uptake of the nanoformulated CBD than the isolate and oil\u2010based forms. Overall, this workflow provides a reliable and accessible approach for nanoformulated CBD analysis, supporting nanopharmaceutical research and routine quality control.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70250","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:02:10Z","timestamp":1790467330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Validated QuEChERS\u2013HPLC\u2013UV Method for Quantification of Cannabidiol in Pharmaceutical Nanoformulations"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6972-7551","authenticated-orcid":false,"given":"Pimpisa","family":"Chaobon","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kasetsart University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phichaporn","family":"Bunwatcharaphansakun","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA)  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehsirinnad","family":"Supattanachote","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kasetsart University  Bangkok Thailand"},{"name":"Center of Excellence for Innovation in Chemistry (PERCH\u2010CIC) Ministry of Higher Education, Science, Research and Innovation (MHESI)  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-9388","authenticated-orcid":false,"given":"Katawut","family":"Namdee","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC) National Science and Technology Development Agency (NSTDA)  Pathumthani Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3474-3545","authenticated-orcid":false,"given":"Thitaphat","family":"Ngernsutivorakul","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Kasetsart University  Bangkok Thailand"},{"name":"Center of Excellence for Innovation in Chemistry (PERCH\u2010CIC) Ministry of Higher Education, Science, Research and Innovation (MHESI)  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/epi.12631","article-title":"Cannabidiol: Pharmacology and Potential Therapeutic Role in Epilepsy and Other Neuropsychiatric Disorders","volume":"55","author":"Devinsky O.","year":"2014","journal-title":"Epilepsia"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2017.02.041","article-title":"Cannabidiol: State of the Art and New Challenges for Therapeutic Applications","volume":"175","author":"Pisanti S.","year":"2017","journal-title":"Pharmacology & Therapeutics"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"119812","DOI":"10.1016\/j.ijpharm.2020.119812","article-title":"Cannabidiol Aqueous Solubility Enhancement: Comparison of Three Amorphous Formulations Strategies Using Different Type of Polymers","volume":"589","author":"Koch N.","year":"2020","journal-title":"International Journal of Pharmaceutics"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"14514","DOI":"10.3390\/ijms241914514","article-title":"Current Challenges and Opportunities for Improved Cannabidiol Solubility","volume":"24","author":"Hossain K. 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