{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:59:23Z","timestamp":1790319563272,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>\n                    <jats:italic>Gagea granatellii<\/jats:italic>\n                    was evaluated for its targeted phenolic profile, antioxidant capacity, antimicrobial activity, urease\u2010inhibitory potential, cytotoxicity, and mineral content. Liquid chromatography\u2013heated electrospray ionization tandem mass spectrometry (LC\u2013HESI\u2013MS\/MS) analysis of 29 targeted phenolic compounds revealed kaempferol as the dominant compound in the flower ethanol extract (211.948 \u00b5g\/g dry weight). In bulb extracts, ellagic acid was highest in the methanol extract (6.925 \u00b5g\/g), whereas syringic aldehyde (5.564 \u00b5g\/g) and ferulic acid (2.619 \u00b5g\/g) were prominent in the water extract. Among the biological assays, the flower water extract showed the strongest 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) radical scavenging activity, with a half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 0.003\u2009mg\/mL, whereas the flower methanol extract exhibited the strongest antibacterial activity against\n                    <jats:italic>Streptococcus pyogenes<\/jats:italic>\n                    , with a minimum inhibitory concentration (MIC) of 0.097\u2009mg\/mL. The bulb ethanol extract showed the strongest urease inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 6.01\u2009mg\/mL). Mineral analysis revealed high potassium and calcium contents, particularly in flowers, while cytotoxicity assays indicated biocompatibility up to 500 \u00b5g\/mL. The findings of the present study indicate that\n                    <jats:italic>G. granatellii<\/jats:italic>\n                    is a promising source of phenolic constituents with antioxidant, antimicrobial, urease\u2010inhibitory, and biocompatible properties.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70255","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:33:14Z","timestamp":1790256794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeted Phenolic Profile, Biological Activities, Cytotoxicity, and Mineral Content of\n                    <i>Gagea granatellii<\/i>\n                    (Liliaceae)"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4091-9033","authenticated-orcid":false,"given":"\u00d6mer","family":"Kayir","sequence":"first","affiliation":[{"name":"Scientific, Technical, Application and Research Center Hitit University  \u00c7orum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Scientific, Technical, Application and Research Center Hitit University  \u00c7orum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-9646","authenticated-orcid":false,"given":"\u00d6mer Koray","family":"Yaylaci","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Department of Pharmaceutical Botany Anadolu University  Eski\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Bilici","sequence":"additional","affiliation":[{"name":"Chemical Engineering Faculty of Engineering and Natural Sciences Hitit University  \u00c7orum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Alver","sequence":"additional","affiliation":[{"name":"Chemical Engineering Faculty of Engineering and Natural Sciences Hitit University  \u00c7orum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu\u011fba","family":"Uysal Kili\u00e7","sequence":"additional","affiliation":[{"name":"Molecular Biology and Genetics Faculty of Engineering and Natural Sciences Hitit University  \u00c7orum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.31901\/24566772.2018\/12.02.559"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28041845"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013310809275"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201402700301"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2019.1612059"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10942912.2022.2157425"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201077574\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/horticulturae8100914"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21577\/0103\u20105053.20160208"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.5c08586"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113323"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113852"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.11646\/phytotaxa.230.2.1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010017\u20109705\u20100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300416"},{"key":"e_1_2_10_17_1","first-page":"369","article-title":"New Records on the Flora of the Gjirokastra Region (South Albania)","volume":"7","author":"Malo S.","year":"2008","journal-title":"Natura Montenegrina"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202201186"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201095203\u20107"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5344\/ajev.1977.28.1.49"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/1811199a0"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr11082248"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5264\/eiyogakuzashi.44.307"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891\u20105849(98)00315\u20103"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2015.11.005"},{"key":"e_1_2_10_26_1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing; Seventeenth Informational Supplement. 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