{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:51:57Z","timestamp":1791939117555,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemPlusChem"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>\n                    Flavonoid\u2013oxidovanadium(IV) (VO) complexes have been widely investigated as anticancer agents because of their ability to induce oxidative stress in tumor cells. In contrast, Zn complexes with ligands capable of reducing intracellular reactive oxygen species (ROS) may exert antitumor effects through a reductive\u2010stress mechanism. Herein, we report the synthesis and characterization of a Zn\u2013troxerutin complex, its interaction with bovine serum albumin (BSA), and its anticancer activity. This study aims to correlate the chemical and biological properties of the complex after replacing a redox\u2010active metal ion with a redox\u2010inactive one. The Zn\u2013troxerutin complex exhibited the same coordination mode and 1:1 metal\u2010to\u2010ligand stoichiometry as the VO analog. It showed dose\u2010dependent antiproliferative activity at higher concentrations in A549, MDA\u2010MB\u2010231, and HCT\u2010116 cancer cells, while reducing intracellular ROS. In HCT\u2010116 cells, reductive stress was associated with increased glutathione (GSH) levels and mitochondrial membrane depolarization. The complex displayed greater anticancer efficacy than free troxerutin and selectivity toward cancer cells over normal HEK293 cells. BSA binding studies yielded positive \u0394\n                    <jats:italic>H<\/jats:italic>\n                    and \u0394\n                    <jats:italic>S<\/jats:italic>\n                    values, indicating that hydrophobic interactions drive complex formation, with binding constants within the optimal range for drug transport. These findings highlight Zn\u2013troxerutin as a promising anticancer agent acting through reductive\u2010stress pathways.\n                  <\/jats:p>","DOI":"10.1002\/cplu.70262","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:34:42Z","timestamp":1791938082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Oxidative to Reductive Stress: Metal\u2010Dependent Mechanisms of Cancer Cell Death in Troxerutin Complexes"],"prefix":"10.1002","volume":"91","author":[{"given":"A.","family":"Vel\u00e1squez Bravo","sequence":"first","affiliation":[{"name":"Cequinor, Conicet\/Unlp Facultad de Ciencias Exactas Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Actis Dato","sequence":"additional","affiliation":[{"name":"Cequinor, Conicet\/Unlp Facultad de Ciencias Exactas Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5143-8390","authenticated-orcid":false,"given":"L. G.","family":"Naso","sequence":"additional","affiliation":[{"name":"Cequinor, Conicet\/Unlp Facultad de Ciencias Exactas Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. G.","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Cequinor, Conicet\/Unlp Facultad de Ciencias Exactas Universidad Nacional de La Plata  La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1549-5873","authenticated-orcid":false,"given":"P. A. 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