{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:47:38Z","timestamp":1791002858214,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CP Mouse Biology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hookworm infections (\n                    <jats:italic>Necator americanus<\/jats:italic>\n                    or\n                    <jats:italic>Ancylostoma duodenale<\/jats:italic>\n                    ) represent a major neglected tropical disease, affecting approximately 700 million people worldwide, and can cause severe morbidity due to the need for these worms to feed on host blood.\n                    <jats:italic>N. brasiliensis<\/jats:italic>\n                    and\n                    <jats:italic>H. polygrus<\/jats:italic>\n                    , both rodent parasites, are the two most commonly employed laboratory models of experimental hookworm infection. Both parasites evoke type 2 immune responses, and their use has been instrumental in generating fundamental insight into the molecular mechanisms of type\u20102 immunity and for understanding how the immune response can control parasite numbers. Here we provide a complete set of methods by which to investigate the natural progression of infection and the host immunological responses in the lung and intestine of\n                    <jats:italic>H. polygyrus<\/jats:italic>\n                    \u2013 and\n                    <jats:italic>N. brasiliensis<\/jats:italic>\n                    \u2013infected mice. Detailed information is included about the most important parasitological and immunological measurements to perform at each time point. \u00a9 2017 by John Wiley &amp; Sons, Inc.\n                  <\/jats:p>","DOI":"10.1002\/cpmo.34","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T08:08:41Z","timestamp":1514016521000},"page":"236-286","source":"Crossref","is-referenced-by-count":47,"title":["The Study of Host Immune Responses Elicited by the Model Murine Hookworms\n                    <i>Nippostrongylus brasiliensis<\/i>\n                    and\n                    <i>Heligmosomoides polygyrus<\/i>"],"prefix":"10.1002","volume":"7","author":[{"given":"T.","family":"Bouchery","sequence":"first","affiliation":[{"name":"Global Health Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Volpe","sequence":"additional","affiliation":[{"name":"Global Health Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Shah","sequence":"additional","affiliation":[{"name":"Global Health Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lebon","sequence":"additional","affiliation":[{"name":"Global Health Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Filbey","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"LeGros","sequence":"additional","affiliation":[{"name":"Malaghan Institute of Medical Research  Wellington New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Harris","sequence":"additional","affiliation":[{"name":"Global Health Institute, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2014.06.003"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1079\/9780851994215.0000"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2199"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1451"},{"key":"e_1_2_23_6_1","doi-asserted-by":"crossref","first-page":"6.28:6.28.1","DOI":"10.1002\/0471142956.cy0628s51","article-title":"Measurement of T cell activation after 16\u2010hr in vitro stimulation with concanavalin A","volume":"51","author":"Arneth B. 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