{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:45:03Z","timestamp":1753868703374,"version":"3.41.2"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["currentprotocols.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["CP Nucleic Acid Chemistry"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tandem catalysis has been at the forefront of synthesis in the past decade due to the reduction in the number of steps and purification needed for the synthesis of commercially relevant molecules. With the right combination of catalyst systems, which could be homometallic or multimetallic, one can construct complex structural motifs in a one\u2010pot procedure without the requirement for the isolation of the intermediates, reducing both reagent waste and time. Over the years, application of tandem catalysis has certainly extended towards arene and heteroarene motifs; nucleoside modification using such a strategy has been rare. In this regard, we would like to report herein the development of numerous homometallic and multimetallic tandem catalytic protocols for the modification of nucleosides, providing efficient access to a diverse range of molecules with promising fluorescent properties, as well as pharmaceutically relevant antiviral drugs such as FV\u2010100. \u00a9 2020 Wiley Periodicals LLC.<\/jats:p><jats:p><jats:bold>Basic Protocol 1<\/jats:bold>: Double tandem one\u2010pot Sonogashira\/cyclization of 5\u2010IdU for the synthesis of FV\u2010100 and analogs<\/jats:p><jats:p><jats:bold>Basic Protocol 2<\/jats:bold>: Double tandem one\u2010pot Heck\/Suzuki\u2013Miyaura of 5\u2010IdU for the synthesis of fluorescent nucleoside analogs<\/jats:p><jats:p><jats:bold>Basic Protocol 3<\/jats:bold>: Double tandem one\u2010pot Suzuki\u2013Miyaura cross\u2010coupling of 5\u2010IdU for the synthesis of fluorescent nucleoside analogs<\/jats:p><jats:p><jats:bold>Basic Protocol 4<\/jats:bold>: Double tandem one\u2010pot amination\/amidation for the synthesis of Sangivamycin precursor<\/jats:p><jats:p><jats:bold>Basic Protocol 5<\/jats:bold>: Triple tandem one\u2010pot chemoselective etherification\/Sonogashira coupling\/cyclization for synthesis of BCNA analogs<\/jats:p><jats:p><jats:bold>Basic Protocol 6<\/jats:bold>: Triple tandem one\u2010pot sequential Heck\/borylation\/Suzuki\u2010Miyaura reaction<\/jats:p>","DOI":"10.1002\/cpnc.117","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T19:31:03Z","timestamp":1601494263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tandem Homometallic or Multimetallic Catalysis for Assembly of Base\u2010Modified Nucleosides"],"prefix":"10.1002","volume":"83","author":[{"given":"Harshita","family":"Shet","sequence":"first","affiliation":[{"name":"Department of Chemistry, Institute of Chemical Technology\u2010Indian Oil Odisha Campus IIT Kharagpur Extension Centre, Mouza Samantpuri  Bhubaneswar Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shatrughn","family":"Bhilare","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology  Mumbai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh S.","family":"Sanghvi","sequence":"additional","affiliation":[{"name":"Rasayan Inc.  Encinitas California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant R.","family":"Kapdi","sequence":"additional","affiliation":[{"name":"Institute of Chemical Technology  Mumbai India"},{"name":"Department of Chemistry, Institute of Chemical Technology\u2010Indian Oil Odisha Campus IIT Kharagpur Extension Centre, Mouza Samantpuri  Bhubaneswar Odisha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2006.06.132"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkf037"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53223-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA19039A"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1690190"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500208k"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-811292-2.00006-4"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201900419"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201701478"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01152H"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200485262"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.6b01612"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2262"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CS00787B"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990346o"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142700.nca03es03"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142700.nca03ds34"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3184\/030823404323000846"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9783527681020","volume-title":"Cooperative catalysis: Designing efficient catalysts for synthesis","author":"Peters R.","year":"2015"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr900301e"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)95769-1"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.4.544"}],"container-title":["Current Protocols in Nucleic Acid Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpnc.117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cpnc.117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cpnc.117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T10:06:16Z","timestamp":1693735576000},"score":1,"resource":{"primary":{"URL":"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/cpnc.117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/cpnc.117"],"URL":"https:\/\/doi.org\/10.1002\/cpnc.117","archive":["Portico"],"relation":{},"ISSN":["1934-9270","1934-9289"],"issn-type":[{"type":"print","value":"1934-9270"},{"type":"electronic","value":"1934-9289"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"assertion":[{"value":"2020-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e117"}}